Volume 121, Issue 3, Pages (September 2001)

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Volume 121, Issue 3, Pages 668-677 (September 2001) Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis- ectodermal dystrophy Petra Obermayer–Straub, Jaakko Perheentupa, Sabine Braun, Anne Kayser, Ayse Barut, Stefanie Loges, Andrea Harms, Georgios Dalekos, Christian P. Strassburg, Michael P. Manns Gastroenterology Volume 121, Issue 3, Pages 668-677 (September 2001) DOI: 10.1053/gast.2001.27103 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 Prevalence of hepatic autoantibodies in patients with APECED. anti-LC, anti-liver cytosol; CYP, cytochrome P450. Gastroenterology 2001 121, 668-677DOI: (10.1053/gast.2001.27103) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 Prevalence of anti-CYP2D6, anti-CYP2A6, and anti-CYP1A2 in APECED patients, with and without hepatitis, in patients with AIH-1, AIH-2, and in nonhepatic control groups. Immunoprecipitation of [35S]-labeled recombinant proteins was performed to screen for autoantibodies directed against (A) CYP2D6, (B) CYP2A6, and (C) CYP1A2. Cut-off values representing the mean value of Finnish healthy controls ± 3SD are 6.1 U for anti-CYP1A2, 25 U for anti-CYP2A6, and 12.9 U for CYP2D6. Gastroenterology 2001 121, 668-677DOI: (10.1053/gast.2001.27103) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 Autoantibodies directed against CYP1A2 and CYP2A6 do not cross-react with other CYPs. Western blots were performed with microsomes derived from AHH-1 TK+/-derived cell lines, expressing individual CYP isoforms. Western blots were performed with (A) a serum positive for CYP1A2 and (B) a serum positive for CYP2A6. The positions of molecular weight markers are indicated on the right border of the Western blots. Gastroenterology 2001 121, 668-677DOI: (10.1053/gast.2001.27103) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 4 Shift in autoantibody patterns in E.B., a patient with APECED hepatitis. Sera obtained from patient EB at different time points were investigated by (A) Western blot and (B) immunoprecipitation with [35S]-labeled protein. Molecular weights as determined with labeled molecular weight standards are indicated on the left border of the Western blots and positive signals obtained with recombinant CYPs expressed in AHH-1 are indicated by arrows. (C) Coincidence of decrease of the anti-CYP1A2 titer and histologic improvement in patient P.S. Sera obtained from patient P.S. at different time points were investigated by immunoprecipitation with [35S]-labeled CYP1A2. The results obtained by liver biopsies are indicated on the top. Gastroenterology 2001 121, 668-677DOI: (10.1053/gast.2001.27103) Copyright © 2001 American Gastroenterological Association Terms and Conditions