Lessons taught by acute promyelocytic leukemia cure

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Presentation transcript:

Lessons taught by acute promyelocytic leukemia cure Hugues de Thé The Lancet Volume 386, Issue 9990, Pages 247-248 (July 2015) DOI: 10.1016/S0140-6736(15)61278-8 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure Mechanism of leukaemia eradication by arsenic and retinoic acid Arsenic and retinoic acid bind the promyelocytic leukaemia (PML) and retinoic acid receptor-α (RARα) moieties of the PML–RARα fusion oncoprotein, respectively, triggering its degradation. This allows PML to activate p53 specifically in acute promyelocytic leukemia (APL) blasts, resulting in leukaemia eradication. The Lancet 2015 386, 247-248DOI: (10.1016/S0140-6736(15)61278-8) Copyright © 2015 Elsevier Ltd Terms and Conditions