Qi Shen, M. D. , Ying Hua, M. D. , Ph. D. , Wenxiao Jiang, M. D

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Presentation transcript:

Effects of mifepristone on uterine leiomyoma in premenopausal women: a meta- analysis Qi Shen, M.D., Ying Hua, M.D., Ph.D., Wenxiao Jiang, M.D., Wenwen Zhang, M.D., Miaomiao Chen, M.D., Xueqiong Zhu, M.D., Ph.D. Fertility and Sterility Volume 100, Issue 6, Pages 1722-1726.e10 (December 2013) DOI: 10.1016/j.fertnstert.2013.08.039 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Flow diagram for the literature search. RCT = randomized controlled trial. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Compared with placebo, the effects of mifepristone on (A) change of uterine volume, (B) change of leiomyoma volume. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Compared with 10 mg/d, the effects of mifepristone 5 mg/d on (A) change of uterine volume, (B) change of leiomyoma volume. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Compared with 6 months of mifepristone treatment, the effects of 3 months of mifepristone on (A) change of uterine volume, (B) relief of pelvic pain, (C) change of hemoglobin level. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Compared with placebo, the effects of mifepristone on (A) relief of pelvic pain, (B) relief of pelvic pressure. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Compared with placebo, effects of mifepristone on (A) relief of dysmenorrhea, (B) relief of hypermenorrhea, (C) change of mean menstrual blood loss, (D) increase of hemoglobin level. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Compared with placebo, the effects of mifepristone on (A) change of endometrial thickness, (B) hyperplasia with atypia in endometrium, (C) after surgery. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 4 Compared with 10 mg/d, the effects of mifepristone 5 mg/d on (A) relief of pelvic pain, (B) relief of pelvic pressure. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 5 Compared with 10 mg/d, the effects of mifepristone 5 mg/d on (A) change of endometrial thickness, (B) relief of hypermenorrhea, (C) elevated liver transaminase levels, (D) hot flushes. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 6 Compared with 5 mg/d, the effects of mifepristone 2.5 mg/d on (A) change of uterine volume, (B) change of leiomyoma volume, (C) relief of pelvic pain, (D) relief of pelvic pressure. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 7 Compared with 5 mg/d, the effects of mifepristone 2.5 mg/d on (A) relief of hypermenorrhea, (B) change of hemoglobin level, (C) change of endometrial thickness. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 8 Compared with 6 months of mifepristone treatment, the effects of 3 months of mifepristone on (A) health-related quality of life, (B) relief of bleeding. Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 9 Sensitivity analysis. (A) Mifepristone 5 mg/d compared with 10 mg/d, relief of pelvic pain; (B) mifepristone 5 mg/d compared with 10 mg/d, relief of pelvic pain (excluding Eisinger 2003 as a low Jadad score). Fertility and Sterility 2013 100, 1722-1726.e10DOI: (10.1016/j.fertnstert.2013.08.039) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions