Human sPD1-based HIV-1 Gag-fusion DNA vaccine induces high frequency of broadly reactive T cell responses in mice and rhesus macaques Samantha MY Chen.

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Presentation transcript:

Human sPD1-based HIV-1 Gag-fusion DNA vaccine induces high frequency of broadly reactive T cell responses in mice and rhesus macaques Samantha MY Chen The mosaic-like immunogen design was based on the circulating HIV-1 subtypes in China The novel DNA vaccine contain human sPD1 fused together with two Gag p41 The vaccine-induced immunogenic response and protection was explored in BALB/c mice We further investigated this DNA vaccine in rhesus macaques to prove concept. JCI. 2013;123(6):2629-42 HKU5/CRF/13G and ITS/194/13

huPD1-Gag fusion DNA vaccine induces strong T-cell response in BALB/c Partial protection against EcoHIV HKU5/CRF/13G and ITS/194/13

Broad T-cell response in Rhesus macaques after vaccination Red and orange/yellow are epitope specific CD8 T cell epitopes associated with HIV control. Green/light blue, purple and blue targets the initial immunodominant CD8 T cell response in early HIV-1 infection. Pink/grey is the immunoprevalent HIV CD4 T cell epitope observed in elite controllers T-cell epitope mapping Boosting effect of DNA vaccine Broad reactivity to HIV subtypes HKU5/CRF/13G and ITS/194/13