Volume 362, Issue 9400, Pages (December 2003)

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Volume 362, Issue 9400, Pages 1953-1958 (December 2003) Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys Dr Thomas W Geisbert, PhD, Lisa E Hensley, PhD, Peter B Jahrling, PhD, Tom Larsen, DvM, Joan B Geisbert, Jason Paragas, PhD, Howard A Young, PhD, Terry M Fredeking, PhD, William E Rote, PhD, George P Vlasuk, PhD The Lancet Volume 362, Issue 9400, Pages 1953-1958 (December 2003) DOI: 10.1016/S0140-6736(03)15012-X Copyright © 2003 Elsevier Ltd Terms and Conditions

Figure 1 Kaplan-Meier curves comparing survival of rhesus monkeys infected with Ebola virus and treated with placebo or rNAPc2 *Placebo group supplemented with 14 historical controls. The Lancet 2003 362, 1953-1958DOI: (10.1016/S0140-6736(03)15012-X) Copyright © 2003 Elsevier Ltd Terms and Conditions

Figure 2 Effect of treatment with rNAPc2 on Ebola virus plasma viraemia Data are mean (SD). The Lancet 2003 362, 1953-1958DOI: (10.1016/S0140-6736(03)15012-X) Copyright © 2003 Elsevier Ltd Terms and Conditions

Figure 3 Gross appearance and histological characteristics associated with rNAPc2-treatment of rhesus monkeys infected with Ebola virus A=typical right arm of rNAPc2-treated survivor at day 10 post infection. B=severe petechial rash of right arm of untreated positive control at day 9 post infection. C=PTAH stain of spleen from rNAPc2-treated monkey euthanised when moribund on day 13, showing no evidence of polymerised fibrin. D=PTAH stain of typical spleen from untreated positive control monkey euthanised when moribund on day 9, showing abundance of polymerised fibrin. The Lancet 2003 362, 1953-1958DOI: (10.1016/S0140-6736(03)15012-X) Copyright © 2003 Elsevier Ltd Terms and Conditions

Figure 4 Effect of treatment with rNAPc2 on coagulation responses during infection of rhesus monkeys Data are mean (SD). The Lancet 2003 362, 1953-1958DOI: (10.1016/S0140-6736(03)15012-X) Copyright © 2003 Elsevier Ltd Terms and Conditions

Figure 5 Effect of treatment with rNAPc2 on inflammatory markers during infection of rhesus monkeys Data are mean (SD). The Lancet 2003 362, 1953-1958DOI: (10.1016/S0140-6736(03)15012-X) Copyright © 2003 Elsevier Ltd Terms and Conditions