Nitrous oxide (N2O) reduces postoperative opioid-induced hyperalgesia after remifentanil–propofol anaesthesia in humans G. Echevarría, F. Elgueta, C.

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Presentation transcript:

Nitrous oxide (N2O) reduces postoperative opioid-induced hyperalgesia after remifentanil–propofol anaesthesia in humans G. Echevarría, F. Elgueta, C. Fierro, D. Bugedo, G. Faba, R. Iñiguez-Cuadra, H.R. Muñoz, L.I. Cortínez British Journal of Anaesthesia Volume 107, Issue 6, Pages 959-965 (December 2011) DOI: 10.1093/bja/aer323 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Flow diagram displaying the progress of all participants through the trial. British Journal of Anaesthesia 2011 107, 959-965DOI: (10.1093/bja/aer323) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 Postoperative pain scores. Values are presented as mean (95% CI). There were no significant differences between the groups (P=0.47). Non-parametric anova with repeated measures in one factor. British Journal of Anaesthesia 2011 107, 959-965DOI: (10.1093/bja/aer323) Copyright © 2011 The Author(s) Terms and Conditions

Fig 3 Postoperative cumulative morphine consumption. Values are presented as mean (95% CI). There were no significant differences between the groups (P=0.83). Non-parametric anova with repeated measures in one factor. British Journal of Anaesthesia 2011 107, 959-965DOI: (10.1093/bja/aer323) Copyright © 2011 The Author(s) Terms and Conditions

Fig 4 von Frey pain thresholds. Values are presented as mean (95% CI). *At 12–18 h after surgery, the baseline-postsurgery decrease in mechanical threshold was greater in the group without N2O than in the group with N2O (non-parametric anova, followed by the Wilcoxon rank-sum test with Bonferroni’s correction, P<0.05). British Journal of Anaesthesia 2011 107, 959-965DOI: (10.1093/bja/aer323) Copyright © 2011 The Author(s) Terms and Conditions