Petr Uher, Petra Baborova, Milena Kralickova, Mathias H

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Presentation transcript:

Non-informative results and monosomies in PGD: the importance of a third round of re- hybridization Petr Uher, Petra Baborova, Milena Kralickova, Mathias H. Zech, Yury Verlinsky, Nicolas H. Zech Reproductive BioMedicine Online Volume 19, Issue 4, Pages 539-546 (October 2009) DOI: 10.1016/j.rbmo.2009.05.008 Copyright © 2009 Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK Terms and Conditions

Figure 1 Percentages of ‘rescued’ results according to the categories analysed. NR, no result. Reproductive BioMedicine Online 2009 19, 539-546DOI: (10.1016/j.rbmo.2009.05.008) Copyright © 2009 Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK Terms and Conditions

Figure 2 (a) Diffused signal for chromosome 18-MultiVysion PGT panel. (b) Second-round hybridization with probes CEP 16 and LSI 22. (c) Re-hybridization of the same nucleus for chromosome 18 with sub-telomeric probes Tel18q. Reproductive BioMedicine Online 2009 19, 539-546DOI: (10.1016/j.rbmo.2009.05.008) Copyright © 2009 Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK Terms and Conditions

Figure 3 (a) Monosomy 18–MultiVysion PGT panel. (b) Second-round hybridization with probes CEP 16 and LSI 22. (c) Re-hybridization of the same nucleus for chromosome 18 with sub-telomeric probe Tel18q. Reproductive BioMedicine Online 2009 19, 539-546DOI: (10.1016/j.rbmo.2009.05.008) Copyright © 2009 Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK Terms and Conditions