Double Duty for CCL21 in Dendritic Cell Trafficking

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Double Duty for CCL21 in Dendritic Cell Trafficking Philip M. Murphy  Immunity  Volume 32, Issue 5, Pages 590-592 (May 2010) DOI: 10.1016/j.immuni.2010.05.004 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 CCL21 Regulation of Mature Dendritic Cell Trafficking to T Cell Zones In this model, proposed by Schumann et al., DCs undergo adhesive random migration (thin arrows) on fields of immobilized CCL21 (large red symbols) and ICAM-1 (not shown) that becomes directionally biased in response to concentration gradients of truncated soluble CCL21 (small red symbols), generated from the immobilized chemokine by the DC itself. Soluble CCL21 forms gradients and biases the direction of migration (thick arrow). Immunity 2010 32, 590-592DOI: (10.1016/j.immuni.2010.05.004) Copyright © 2010 Elsevier Inc. Terms and Conditions

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