Coordinating Development of Medullary Thymic Epithelial Cells

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Coordinating Development of Medullary Thymic Epithelial Cells Mingzhao Zhu, Yang-Xin Fu Immunity Volume 29, Issue 3, Pages 386-388 (September 2008) DOI: 10.1016/j.immuni.2008.09.001 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Regulation of mTEC Development At the embryonic stage, LTi cells regulate mTEC development and/or organization, whereas positively selected autoreactive CD4+ SP thymocytes regulate further development and/or organization of mTECs in the postnatal thymus. LTi cells likely deliver the RANKL signal to promote the maturation of mTECs. Three TNFRSF members (RANK, CD40, and LTβR) have been found to be involved in mTEC development and/or organization in postnatal thymus. Regulation of mTEC proliferation is at least one of the underlying mechanisms for TNFRSF to control mTEC development. Abbreviations: LTβR, lymphotoxin beta receptor; LTi, lymphoid tissue inducer; mTEC, medullary thymic epithelial cell; RANK, receptor activator of NF-κB. Immunity 2008 29, 386-388DOI: (10.1016/j.immuni.2008.09.001) Copyright © 2008 Elsevier Inc. Terms and Conditions