IL-23/IL-17A Dysfunction Phenotypes Inform Possible Clinical Effects from Anti-IL-17A Therapies  Andrew Blauvelt, Mark G. Lebwohl, Robert Bissonnette  Journal of Investigative Dermatology  Volume 135, Issue 8, Pages 1946-1953 (August 2015) DOI: 10.1038/jid.2015.144 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Role of cytokines in psoriasis pathophysiology and immune defense against infections. (a) Pathophysiology of psoriasis, with indications for the relative positions of key cytokines and their inhibitors. (b) Signaling pathways associated with specific increases in susceptibility to pathogens. HSV, herpes simplex virus; NEMO, NF-kappaB essential modulator; STAT, signal transducer and activator of transcription; TIR, Toll-like receptor/IL-1 receptor; TNF-R, tumor necrosis factor receptor; TYK, tyrosine kinase (Bustamante et al., 2008). Adapted from Bustamante et al., 2008, with permission from Elsevier. Journal of Investigative Dermatology 2015 135, 1946-1953DOI: (10.1038/jid.2015.144) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions