Oxidative stress and gene expression in sepsis

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Presentation transcript:

Oxidative stress and gene expression in sepsis J. Macdonald, H.F. Galley, N.R. Webster British Journal of Anaesthesia Volume 90, Issue 2, Pages 221-232 (February 2003) DOI: 10.1093/bja/aeg034 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 1 A schematic diagram showing the interaction between intracellular antioxidants. O 2 . - =superoxide anion radical; SOD=superoxide dismutase; H2O2=hydrogen peroxide; GSH=reduced GSH (l-γ-glutamyl-l-cysteinyl-glycine); GSSG=oxidized GSH; γGCS=γ-glutamylcysteine synthetase. British Journal of Anaesthesia 2003 90, 221-232DOI: (10.1093/bja/aeg034) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 2 A schematic diagram showing LPS stimulation of the host inflammatory response in monocytes, macrophages and neutrophils. NFκB=nuclear factor κB; AP-1=activator protein 1; NF-IL-6=nuclear factor-interleukin-6; LPS=lipopolysaccharide; LBP=LPS-binding protein; CD14=CD14 surface receptor; TLR4=Toll-like receptor 4; MD-2=accessory protein MD-2; IKK-NFκB=IκB kinase–NFκB pathway; NFκB-IκB=NFκB–inhibitory protein IκB complex; MAPK=mitogen-activated protein kinase pathway; TREM-1=triggering receptor expressed on myeloid cells 1; DAP12=transmembrane adapter molecule DAP12; Nod1 and Nod2=intracellular cytoplasmic proteins Nod1 and Nod2. British Journal of Anaesthesia 2003 90, 221-232DOI: (10.1093/bja/aeg034) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 3 A schematic diagram showing NFκB activation and regulation. LPS=lipopolysaccharide; CYTO=proinflammatory cytokines; ROS=reactive oxygen species; NFκB=nuclear factor κB; NIK=NFκB inducible kinase; IκB=inhibitory protein IκB; TNF-α=tumour necrosis factor α; IL-1β=interleukin-1β; IL-10=interleukin-10. British Journal of Anaesthesia 2003 90, 221-232DOI: (10.1093/bja/aeg034) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions