Effects of Oncotic Pressure and Hematocrit on Outcome After Hypothermic Circulatory Arrest Toshiharu Shin’oka, Dominique Shum-Tim, Peter C Laussen, Sophia.

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Presentation transcript:

Effects of Oncotic Pressure and Hematocrit on Outcome After Hypothermic Circulatory Arrest Toshiharu Shin’oka, Dominique Shum-Tim, Peter C Laussen, Sophia M Zinkovsky, Hart G.W Lidov, Adre du Plessis, Richard A Jonas The Annals of Thoracic Surgery Volume 65, Issue 1, Pages 155-164 (January 1998) DOI: 10.1016/S0003-4975(97)00909-0

Fig. 1 Flow diagram depicting experimental protocol. (AST = aspartate aminotransferase; ALT = alanine aminotransferase; ALP = alkaline phosphatase; CK = creatine kinase; DHCA = deep hypothermic circulatory arrest; LDH = lactate dehydrogenase; MRS = magnetic resonance spectroscopy; NIRS = near-infrared spectroscopy; T.Bil = total bilirubin.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)

Fig. 2 Percentage change of body weight 3 hours after cardiopulmonary bypass (0POD), and on postoperative day 1 (1POD) and 4 (4POD). (Gp = group; Hct = hematocrit; Heta = hetastarch; MUF = modified ultrafiltration; Penta = pentafraction.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)

Fig. 3 Colloid oncotic pressure before and 3 hours after cardiopulmonary bypass (CPB). (Gp = group; Hct = hematocrit; Heta = hetastarch; MUF = modified ultrafiltration; Penta = pentafraction.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)

Fig. 4 Percentage change in total body water content calculated by bioelectrical impedance. (Gp = group; Hct = hematocrit; Heta = hetastarch; MUF = modified ultrafiltration; Penta = pentafraction.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)

Fig. 5 Results of magnetic resonance spectroscopy. (A) Cerebral adenosine triphosphate (ATP) level. (B) Cerebral phosphocreatine (PCr) level. (C) Cerebral intracellular pH. (DHCA = deep hypothermic circulatory arrest; Gp = group; Hct = hematocrit; Heta = hetastarch; microMxDPF = differential path length factor; MUF = modified ultrafiltration; Penta = pentafraction.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)

Fig. 6 Results of near-infrared spectroscopy. (A) Oxyhemoglobin level. (B) Deoxyhemoglobin level. (C) Total hemoglobin level. (D) Cytochrome a,a3 level. (DHCA = deep hypothermic circulatory arrest; Gp = group; Hct = hematocrit; Heta = hetastarch; microMxDPF = differential path length factor; MUF = modified ultrafiltration; Penta = pentafraction.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)

Fig. 7 Neurologic deficit (ND) score. (Gp = group; Hct = hematocrit; Heta = hetastarch; MUF = modified ultrafiltration; Penta = pentafraction; POD = postoperative day.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)

Fig. 8 Overall performance categories (OPC). (Gp = group; Hct = hematocrit; Heta = hetastarch; MUF = modified ultrafiltration; Penta = pentafraction; POD = postoperative day.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)

Fig. 9 Histologic score for neocortex, hippocampus, and caudate nucleus. (Gp = group; Hct = hematocrit; Heta = hetastarch; MUF = modified ultrafiltration; Penta = pentafraction.) The Annals of Thoracic Surgery 1998 65, 155-164DOI: (10.1016/S0003-4975(97)00909-0)