Impact of Statins on Physical Activity and Fitness: Ally or Adversary?

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Impact of Statins on Physical Activity and Fitness: Ally or Adversary? Barry A. Franklin, PhD Mayo Clinic Proceedings Volume 90, Issue 10, Pages 1314-1319 (October 2015) DOI: 10.1016/j.mayocp.2015.08.014 Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Comparison of the effects of exercise training and statins on varied risk factors and health outcome modulators in the prevention of initial and recurrent cardiovascular events. Although both regular exercise and statins appear to confer substantial reductions in cardiovascular mortality, there are numerous independent and additive benefits of exercise over statins when other variables are considered.29 Mayo Clinic Proceedings 2015 90, 1314-1319DOI: (10.1016/j.mayocp.2015.08.014) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Mortality risk, expressed as fully adjusted hazard ratios and 95% CIs, for combined cardiorespiratory fitness and statin categories. Patients with a peak MET value of 5.0 or less were classified as “least fit”; those with a peak MET value of 5.1 to 7.0 were classified as “moderately fit”; those with a peak MET value of 7.1 to 9.0 were classified as “fit”; and those with a peak MET value greater than 9.0 were classified as “highly fit.”16 Mayo Clinic Proceedings 2015 90, 1314-1319DOI: (10.1016/j.mayocp.2015.08.014) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions