Elevated cardiac 3-deoxyglucosone, a highly reactive intermediate in glycation reaction, in doxorubicin-induced cardiotoxicity in rats Tomoyuki Moriyama,

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Elevated cardiac 3-deoxyglucosone, a highly reactive intermediate in glycation reaction, in doxorubicin-induced cardiotoxicity in rats Tomoyuki Moriyama, Masayuki Kemi, Toshiharu Horie Pathophysiology Volume 23, Issue 3, Pages 237-242 (September 2016) DOI: 10.1016/j.pathophys.2016.08.001 Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 1 Myocardial 3-DG levels in rats treated with saline (Control) or 2 mg/kg DXR intravenously once a week for 4 or 6 weeks. Data are presented as the mean±S.E. (n=5–6). Statistical analysis was performed using the Student’s t-test. **p<0.05 vs. control group. Pathophysiology 2016 23, 237-242DOI: (10.1016/j.pathophys.2016.08.001) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 2 Myocardial pentosidine levels in rats treated with saline (Control) or 2 mg/kg DXR intravenously once a week for 4 or 6 weeks. Data are presented as the mean±S.E. (n=5–6). Statistical analysis was performed using the Student’s t-test. **p<0.05 vs. control group. Pathophysiology 2016 23, 237-242DOI: (10.1016/j.pathophys.2016.08.001) Copyright © 2016 Elsevier B.V. Terms and Conditions

Fig. 3 Histopathological sections of the rat heart after 6 weekly treatments to rats with saline i.v. (A, control), DXR 2mg/kg i.v. (B), DXR 2mg/kg i.v.+AG 25mg/kg/day i.p. (C and D), and DXR 2mg/kg i.v.+PM 60mg/kg/day i.p. (E and F). Slight intracytoplasmic vacuolation was observed in the myocardial fibers in the left ventricles (arrow heads) in the DXR-alone group (B: graded as slight) but to a lesser degree in the DXR+AG group (C: normal and D: graded as very slight) or the DXR+PM group (E: normal and D: graded as very slight). Hematoxylin and eosin stain. Pathophysiology 2016 23, 237-242DOI: (10.1016/j.pathophys.2016.08.001) Copyright © 2016 Elsevier B.V. Terms and Conditions