APPLICATION TO THE HADROTHERAPY FOR OCULAR MELANOMAS In this talk I would like to explain the reasons are bring us to work with G4 and the goals we wold like to obtain with its use. We are the only italian prothontherapy center and actually we treated 15 patients G.A. Pablo Cirrone Qualified Medical Physicist and PhD Student University of Catania and Laboratori Nazionali del Sud INFN, Italy

LNS Superconducting Cyclotron in Catania is the unique machine in in Italy and South Europe used for protontherapy

Depth doses in radiotherapy: single fields

Why clinical proton beams? penetration depth is well-defined and adjustable most energy at end-of -range protons travel in straight lines dose to normal tissue minimised no dose beyond target

MEDICAL APPLICATION OF THE CATANA FACILITY Choroidal Melanoma 85 - 90 % successfully treating with proton beams About 300 new cases for year in Italy In the world 5000 patients have been already treated with proton beams Age related subfoveal macular degenerations with subretinal neovascular membrane This is the main cause of third age blindness in EC countries It is a “social disease” for EC INFN - LNS

LAYOUT OF LNS 0 ° respect the switching magnet PRESENT TREATMENT ROOM 0 ° respect the switching magnet 80 meter after extraction 3 m proton beam line LAYOUT OF LNS

Scattering system Modulator & Range shifter Ligth field Laser Scattering system Monitor chambers

Patient ready for treatment

Irradiated GAF Chromic DETECTORS USED FOR DOSE DISTRIBUTION MEASUREMENTS DEPTH DOSE DISTRIBUTION LATERAL DOSE DISTRIBUTION Markus Ionization chamber Silicon diode GAF Chromic Film Thermoluminescent dosimeters 2 mm Sensible Volume = 0.05 cm3 Markus Chamber layout Irradiated GAF Chromic Risolution 100 m for DDP and 200 m for LDP

‘PURE’ BRAGG PEAK EXPERIMENTAL RESULTS

MODULATED BRAGG PEAK

EXPERIMENTAL LATERAL DOSE DISTRIBUTION

Geant4 applications in prothon therapy our goals Simulation, design and realization of critical elements of a proton beam line Scattering system Modulation system Collimators along the beam line Three dimensions dose distribution verification in water at isocenter in the treatment conditions Comparison with experimental and treatment planning data

Proton therapy group in Catania G. Cuttone Project Leader INFN G.A.P. Cirrone Qualified Medical Physicist and PhD student V. Salamone L. Raffaele M.G. Sabini L. Valastro P. Lojacono V. Patti Qualified Medical Physicist Student for Medical Physics Qualification