A History of Bone Marrow Transplantation

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A History of Bone Marrow Transplantation M. Teresa de la Morena, MD, Richard A. Gatti, MD Hematology/Oncology Clinics Volume 25, Issue 1, Pages 1-15 (February 2011) DOI: 10.1016/j.hoc.2010.11.001 Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 1 GVHD in a patient who developed fever, maculopapular rash, hepatosplenomegaly, pancytopenia, and death. Hematology/Oncology Clinics 2011 25, 1-15DOI: (10.1016/j.hoc.2010.11.001) Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 2 Patient family pedigree. (Adapted from Good RA. Immunologic reconstitution: the achievement and it's meaning. In: Bergsma D, Good RA, editors. Birth defects original articles series, vol. 4. White Plains (NY): The National Foundation-March of Dimes; 1968; with permission.) Hematology/Oncology Clinics 2011 25, 1-15DOI: (10.1016/j.hoc.2010.11.001) Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 3 Histocompatibility testing of an X-SCID patient and family members, using HLA serologic typing and unidirectional MLC. Note that segregation of both HLA haplotyping and MLC reactions were only understandable after a crossover between HLA-A and HLA-B loci was appreciated. Class II loci on haplotype B (asterisks) of the patient would have then segregated with the proximal portion of recombinant haplotype B in Sib3, who became the stem cell donor. (Data from Gatti RA, Meuwissen HJ, Terasaki PI, et al. Recombination within the HL-A locus. Tissue Antigens 1971;1(5):239–41.) Hematology/Oncology Clinics 2011 25, 1-15DOI: (10.1016/j.hoc.2010.11.001) Copyright © 2011 Elsevier Inc. Terms and Conditions