Prospective observational study of the effect of dual antiplatelet therapy with tranexamic acid treatment on platelet function and bleeding after cardiac.

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Prospective observational study of the effect of dual antiplatelet therapy with tranexamic acid treatment on platelet function and bleeding after cardiac surgery J. Amour, M. Garnier, J. Szymezak, Y. Le Manach, D. Helley, S. Bertil, A. Ouattara, B. Riou, P. Gaussem British Journal of Anaesthesia Volume 117, Issue 6, Pages 749-757 (December 2016) DOI: 10.1093/bja/aew357 Copyright © 2016 The Author(s) Terms and Conditions

Fig 1 Study flowchart. CABG: coronary artery bypass graft; IABP: intra-aortic balloon pump British Journal of Anaesthesia 2016 117, 749-757DOI: (10.1093/bja/aew357) Copyright © 2016 The Author(s) Terms and Conditions

Fig 2 Comparison of antiplatelet therapy effect of aspirin (Panel A with arachidonic acid maximal aggregation; cut off at 20%) and clopidogrel [panel B (with ADP 10 µM maximal aggregation; cut off at 50%) and panel C (platelet reactivity index (PRI, %) with vasodilator-stimulated phosphoprotein (VASP) assay; cut off at 60%) in patients treated preoperatively with aspirin (n= 89) and DAPT (n= 61). British Journal of Anaesthesia 2016 117, 749-757DOI: (10.1093/bja/aew357) Copyright © 2016 The Author(s) Terms and Conditions

Fig 3 Correlation between cumulative postoperative bleeding at 24 h and arachidonic acid residual aggregation (%) (Panel A, n = 150), ADP 10 µM residual aggregation (%) (Panel B, n = 150) and platelet reactivity index (PRI, %) with vasodilator-stimulated phosphoprotein (VASP) assay Panel C, (n = 61). British Journal of Anaesthesia 2016 117, 749-757DOI: (10.1093/bja/aew357) Copyright © 2016 The Author(s) Terms and Conditions