Predictive Low Glucose Suspend (PLGS)

Severe Hypoglycemia in People With T1D

How Can Hypoglycemia Be Prevented?

Suspending Insulin for Hypoglycemia Prevention and Avoidance: The Automated Insulin Roadmap

The Beginnings: Low Glucose Suspend (LGS)

PLGS: 12 Years of Evolution

What Is PLGS?

Early PLGS Studies Inpatient (2008-2010)

Further PLGS Studies Outpatient (2013-2015)

PLGS Reduces Nocturnal Hypoglycemia

Medtronic Study (2016)

Tandem PLGS (Basal-IQ™) Inpatient Feasibility Study

Tandem PLGS Linear Regression Algorithm

Tandem PLGS Inpatient Feasibility Study Outcomes

Tandem PLGS Inpatient Feasibility Study

PLGS Patient Example

Tandem PLGS Feasibility Study Results

Tandem Basal-IQ™ Pivotal PROLOG Trial

PROLOG Trial Design

PROLOG Trial Primary Outcome Time < 70 mg/dL (3.9 mmol/L)

PROLOG Trial Median Time < 70 mg/dL During Day and Night

PROLOG Trial Primary Outcome

PROLOG Trial Safety

Enhancing Patient Care With PLGS Clinical Pearl #1: Set Expectations

System Usability Questionnaire (SUS)

Enhancing Patient Care With PLGS Clinical Pearl #2: Alert Settings Are Actionable

Enhancing Patient Care With PLGS Clinical Pearl #3: Treating Hypoglycemia

Conclusions and Key Takeaways

Conclusions and Key Takeaways (cont)

Conclusions and Key Takeaways (cont)

Abbreviations