Protein Structure.

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Presentation transcript:

Protein Structure

Biology/Chemistry of Protein Structure Primary Secondary Tertiary Quaternary Assembly Folding Packing Interaction S T R U C T U R E P R O C E S S

Primary Structure - Sequence

FOLDING

Basic Secondary structure α-helix β-sheet Secondary structures, α-helix and β-sheet, have regular hydrogen-bonding patterns.

1’ > 2’ > 3’ > 4’ > … Tertiary structure Quaternary structure

X - Ray X-ray Diffraction Pattern for a Protein

X-Ray

NMR – there is no right answer

THE database of experimentally-derived structures of proteins, nucleic acids, and complexes Access to structural information Visualization Analysis

PDB Growth and Content Experimental Methods: Macromolecules: X-Ray Crystallography NMR more… Macromolecules: Proteins Nucleic acids Carbohydrates Protein-nucleic acid complexes Protein-carbohydrate complexes

PDB Homepage

An Example – 2ARA

Search Methods

Advanced Search

Sequence Search

Example Results