Nitrate-, nitrite-, and nitric oxide-reducing bacteria.

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Nitrate-, nitrite-, and nitric oxide-reducing bacteria. Nitrate-, nitrite-, and nitric oxide-reducing bacteria. (A) Differential abundances of OTUs as detected by ANCOM that have nitrate-, nitrite-, and nitric acid-producing KEGG orthologies (KOs) as reported by PICRUSt by body site. Oral samples show obvious differences between migraineurs (True) and nonmigraineurs (False) in nitrate, nitrite, or NO reductase genes, while there are no obvious differences in stool samples. However, both nitrate and nitrite are significant in stool samples, but not nitric oxide, as sample groups are too small. (B) Relative abundance profiles of oligotypes (sub-OTUs) in Streptococcus (two oligotypes) and Pseudomonas (five oligotypes). Intergroup analysis revealed no major differences in the Streptococcus distribution profiles. Pseudomonas oligotype 2 was highly enriched in the “TRUE” group (FALSE = 54%, TRUE = 82%). Antonio Gonzalez et al. mSystems 2016; doi:10.1128/mSystems.00105-16