Fig. 1. Anemia in patients with central diabetes insipidus.

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Fig. 1. Anemia in patients with central diabetes insipidus. Anemia in patients with central diabetes insipidus. (A) Ninety-two patients who had central diabetes insipidus were identified at the National Institutes of Health Clinical Center: 45 women (red circles) and 47 men (blue squares). Their hemoglobin, hematocrit, and red blood cell distribution width (RDW) values were averaged for all the measurements made and are depicted by a single, thin red or blue line on the graph. The black line on each graph represents the average values in healthy subjects. The hematocrit and hemoglobin values of these patients are significantly (***P < 0.0001) different from the general U.S. population. (B) Reverse transcription polymerase chain reaction (RT-PCR)–based detection of AVPR1A, AVPR1B, and AVPR2 mRNAs in human CD34+ cells. Lane 1, 100–base pair (bp) ladder; lane 2, RT-PCR product; lane 3, no template. (C) Human CD34+ cells on day 3 of two-phase liquid cultures (immunocytochemistry). All three arginine vasopressin (AVP) receptors are present. AVPR1B appears to be much more abundant than AVPR1A and AVPR2. Scale bars, 10 μm. (D) AVPR1A, AVPR1B, and AVPR2 receptor proteins during erythroid differentiation in two-phase liquid culture (Western blotting). (E) AVP and d(Cha4)-AVP (an AVPR1B agonist) increase intracellular Ca2+ in human hematopoietic stem and progenitor cells (HSPCs). Balázs Mayer et al., Sci Transl Med 2017;9:eaao1632 Published by AAAS