Volume 68, Issue 2, Pages 833-839 (August 2005) Significance of minimodeling in dialysis patients with adynamic bone disease  Yoshifumi Ubara, Tetsuo Tagami, Syohei Nakanishi, Naoki Sawa, Junichi Hoshino, Tatsuya Suwabe, Hideyuki Katori, Fumi Takemoto, Shigeko Hara, Kenmei Takaichi  Kidney International  Volume 68, Issue 2, Pages 833-839 (August 2005) DOI: 10.1111/j.1523-1755.2005.00464.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Minimodeling characterized by hump-like structure (arrows). Polarizing microscopy ×200. Kidney International 2005 68, 833-839DOI: (10.1111/j.1523-1755.2005.00464.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Comparative study of minimodeling bone volume (Mi Mo BV/BV) between patients with hyperparathyroidism necessitating parathyroidectomy and patients with hypoparathyroidism. Results are expressed as means ± SD. Minimodeling bone volume in the hypoparathyroidism group was significantly greater than in the hyperparathyroidism group (P = 0.0028, z score = -2.85). Kidney International 2005 68, 833-839DOI: (10.1111/j.1523-1755.2005.00464.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Correlation between minimodeling bone volume (Mi Mo BV/BV) and total bone volume (BV/TV) in patients with hypoparathyroidism. Minimodeling bone volume showed a significant positive correlation with total bone volume (r2 = 0.304,P = 0.0016). Kidney International 2005 68, 833-839DOI: (10.1111/j.1523-1755.2005.00464.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Correlation between minimodeling bone volume (Mi Mo BV/BV) and total bone volume (BV/TV) in patients with hyperparathyroidism. No significant correlation was found between these two variables (P = 0.66). Kidney International 2005 68, 833-839DOI: (10.1111/j.1523-1755.2005.00464.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 5 Comparison of minimodeling bone volume (Mi Mo BV/BV) between patients with hypoparathyroidism treated with dialysis as outpatients (group B1) and those treated with dialysis as long-term inpatients (group B2). Results are expressed as mean ± SD. Minimodeling bone volume was significantly higher than in the latter group (P < 0.0001, z score = -3.43). Kidney International 2005 68, 833-839DOI: (10.1111/j.1523-1755.2005.00464.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 6 Comparison of total bone volume (BV/TV) between patients with hypoparathyroidism treated with dialysis as outpatients (group B1) and those treated with dialysis as long-term inpatients (group B2). Results are expressed as means ± SD. Total bone volume in the former group was significantly higher than in the latter group (P = 0.025, z score = -2.29). Kidney International 2005 68, 833-839DOI: (10.1111/j.1523-1755.2005.00464.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 7 Correlation between minimodeling bone volume (Mi Mo BV/BV) and age in patients with hypoparathyroidism, Minimodeling bone volume showed significant (negative) correlation with age (r2 = 0.208,P < 0.001). Kidney International 2005 68, 833-839DOI: (10.1111/j.1523-1755.2005.00464.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 8 Correlation between total bone volume (BV/TV) and age in patients with hypoparathyroidism. Total bone volume showed significant (negative) correlation with age (r2 = 0.35,P = 0.005). Kidney International 2005 68, 833-839DOI: (10.1111/j.1523-1755.2005.00464.x) Copyright © 2005 International Society of Nephrology Terms and Conditions