Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic.

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Presentation transcript:

Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome Alessandro D Genazzani, M.D., Ph.D., Cesare Battaglia, M.D., Barbara Malavasi, M.D., Claudia Strucchi, M.D., Francesca Tortolani, M.D., Ombretta Gamba, M.D. Fertility and Sterility Volume 81, Issue 1, Pages 114-119 (January 2004) DOI: 10.1016/j.fertnstert.2003.05.020

FIGURE 1 The ratio of glucose to insulin, an index of sensitivity to insulin, was significantly improved by metformin administration. Before metformin: —. During metformin: - - -. ** P<.01. Genazzani. Metformin restores episodic LH secretion in PCOS.Fertil Steril 2004. Fertility and Sterility 2004 81, 114-119DOI: (10.1016/j.fertnstert.2003.05.020)

FIGURE 2 Episodic LH spontaneous secretion in one PCOS patient under study shows that, after 6 months of treatment, LH pulses were significantly reduced in amplitude with no change in pulse frequency. Arrows indicate statistically significant LH pulses detected by the program DETECT. Before metformin: —. During metformin: - - -. Genazzani. Metformin restores episodic LH secretion in PCOS. Fertil Steril 2004. Fertility and Sterility 2004 81, 114-119DOI: (10.1016/j.fertnstert.2003.05.020)