The Impact of Pain and Itch on Functioning and Health-Related Quality of Life in Systemic Sclerosis: An Exploratory Study  Mélanie Racine, PhD, Marie Hudson, MD, MPH, Murray Baron, MD, Warren R. Nielson, PhD J. Pope, J. Markland, D. Robinson, N. Jones, N. Khalidi, P. Docherty, E. Kaminska, A. Masseto, E. Sutton, J.-P. Mathieu, S. Ligier, T. Grodzicky, C. Thorne, G. Gyger, D. Smith, P.R. Fortin, M. Larché Mélanie Racine, PhD, Marie Hudson, MD, MPH, Murray Baron, MD, Warren R. Nielson, PhD J. Pope, J. Markland, D. Robinson, N. Jones, N. Khalidi, P. Docherty, E. Kaminska, A. Masseto, E. Sutton, J.-P. Mathieu, S. Ligier, T. Grodzicky, C. Thorne, G. Gyger, D. Smith, P.R. Fortin, M. Larché  Journal of Pain and Symptom Management  Volume 52, Issue 1, Pages 43-53 (July 2016) DOI: 10.1016/j.jpainsymman.2015.12.314 Copyright © 2016 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 1 Box-and-whisker plots demonstrating interquartile range (box), median (line), range (whisker), and outliers (dots) of pain and itch severity in a sample of 964 patients with SSc. SSc = systemic sclerosis; NRS = numerical rating scale. Journal of Pain and Symptom Management 2016 52, 43-53DOI: (10.1016/j.jpainsymman.2015.12.314) Copyright © 2016 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 2 Illustration of the effect of pain NRS value on outcome variables at the itch NRS values corresponding to 0 (10th to 25th percentiles), 1 (25th to 50th percentiles), 3 (50th to 75th percentiles), and 6 (75th to 90th percentiles). NRS = numerical rating scale; PROMIS = Patient-Reported Outcome Measurement System. Journal of Pain and Symptom Management 2016 52, 43-53DOI: (10.1016/j.jpainsymman.2015.12.314) Copyright © 2016 American Academy of Hospice and Palliative Medicine Terms and Conditions