Periconceptional maternal biomarkers of one-carbon metabolism and embryonic growth trajectories: the Rotterdam Periconceptional Cohort (Predict Study)  Francesca Parisi, M.D., Melek Rousian, Ph.D., Anton H.J. Koning, Ph.D., Sten P. Willemsen, M.Sc., Irene Cetin, Ph.D., Eric A.P. Steegers, Ph.D., Régine P.M. Steegers-Theunissen, Ph.D.  Fertility and Sterility  Volume 107, Issue 3, Pages 691-698.e1 (March 2017) DOI: 10.1016/j.fertnstert.2016.11.030 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Flowchart of the study population. ART = assisted reproductive technology; CRL = crown-rump length; 3D-US = three-dimensional ultrasound; IUFD = intrauterine fetal death; IUI = intrauterine insemination. Fertility and Sterility 2017 107, 691-698.e1DOI: (10.1016/j.fertnstert.2016.11.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Fully adjusted models for (A) crown-rump length (CRL) and (B) embryonic volume (EV) in relation to total homocysteine (tHcy) concentrations in the total study population. The tHcy concentration is expressed as +2 standard deviations (SD) (dashed line, corresponding to 10.3 μmol/L in the total study population) and −2 SD (continuous line, corresponding to 3.0 μmol/L). Gestational age (GA) is expressed in days. Full adjustment for parity, alcohol use, smoking, folic acid use, maternal age, body mass index, comorbidity, and fetal gender was performed. Fertility and Sterility 2017 107, 691-698.e1DOI: (10.1016/j.fertnstert.2016.11.030) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions