Pathogenic Roles of B Cells in Human Autoimmunity

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Pathogenic Roles of B Cells in Human Autoimmunity Flavius Martin, Andrew C Chan Immunity Volume 20, Issue 5, Pages 517-527 (May 2004) DOI: 10.1016/S1074-7613(04)00112-8

Figure 1 Effector Mechanisms of Human and Mouse B Cell Autoimmunity “Classic” antibody-dependent mechanisms are responsible either directly or through immune complexes for the pathogenesis of specific autoimmune diseases. Several other mechanisms, including antigen presentation (APC), costimulatory functions (surface molecules and secreted cytokines), and the ability to support de novo lymphoid tissue organization (neolymphogenesis) may explain other parts of B cell involvement in complex autoimmune conditions. AchR, acetylcholine receptor; GMB, glomerular basement membrane; FVIII, factor VIII; TSH, thyroid-stimulating hormone; RBC, red blood cells; GPIIb-IIIa, glycoprotein IIb-IIIa; GPIb-IX, glycoprotein Ib-IX; Ag, antigen; B, B cell; T, T cell; FDC, follicular dendritic cell; DC, dendritic cell. Immunity 2004 20, 517-527DOI: (10.1016/S1074-7613(04)00112-8)