Focus of research group – AFib

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Presentation transcript:

Focus of research group – AFib Name PI: Bianca Brundel Department, UMC: Physiology, location VUmc Size of research group: Post-doc: Deli Zhang (Dr. Dekker) and Marit Wiersma (ACS grant) PhD student: Denise van Marion, Xu Hu, Larissa Dorsch, Jin Li Research assistent: Lucienne Baks, Thais van Beuren Partners: Cardiac Arrhythmia Lab: Natasja de Groot (EMC), Alle-Jan van der Veen and Wouter Serdijn (TU Delft) Current mission, vision and aims Improve AF patient-tailored drug treatment and diagnostics by: Uncovering key molecular mechanisms which underlie electropathology and AF onset and progression Identify novel pharmaco-therapeutics which target electropathology and test drugs in clinical AF studies Design diagnostic instruments to determine stage of electropathology

Expertise: Improve AF patient-tailored drug treatment and diagnostics Early diagnosis of AF: structural and electrical AF Fingerprint AF model: Tachypaced Drosophila prepupae Biobank Heart rate Arrhythmicity + Systolic function Diastolic function Fractional Shortening Iuso, Wiersma, Brundel.. AJHG, 2018 Electro-Biomarker AF-induced proteostasis derailment & druggable targets Expansion of research line: AF patients, risk factors for AF (Zhang) Familial AF (Wiersma) Henning and Brundel Nature Rev Cardiology 2017

Current funding: Patient platforms: E.I.: Brundel Junior post-doc: Zhang LSH-TKI / DHF Brundel & De Groot CVON-DOSIS vd Velden,Brundel, Kuster de Boer (UMCG) Asselbergs, v Tintelen (UMCU) Michels (Erasmus MC) CVON / STW: De Groot, Brundel, Serdijn and Van der Veen (TU Delft) Patient platforms: Out-of-box Post doc grant: M. Wiersma

Future plans: Short term (1-2 year) plan Continue molecular and biomarker studies in AF and familiar AF Continue building of AF tissue and blood biobank Conduct clinial trials (collaboration EMC) Attract funding with Cardiac Arrhythmia Lab (Medical Delta: EMC/TUDelft) Necessary infrastructure: available. Long term (>2 year) plan Expand clinical drug studies: multicenter Incorporate AF-fingerprint in daily clinical practice Expand Cardiac Arrhythmia Lab Necessary infrastructure: Setup AF-on-a-Chip: joint efforts of Medical Delta (TUDelft, EMC, Vumc) and Innovation program with German-Dutch SMEs and Universities on heart-on-a-chip program Ongoing collaboration in ACS Genetic Metabolic Diseases: Rob Wust/Riekelt Houtkooper on mitochondrial function Medical biochemistry: Vivian de Waard on use of Drosophila in Nur77 project Clinical genetics: WGS in familial AF (Tintelen, UMCU)