Focus of research group (I)

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Presentation transcript:

Focus of research group (I) Name PI: Carol Ann Remme MD PhD Department, UMC: Experimental Cardiology, AMC Size of research group: 2 postdocs, 4 PhD students, 1 technician Current mission, vision and aims To identify novel disease mechanisms underlying (inherited) arrhythmias and sudden cardiac death To understand (variable) disease expressivity in inherited arrhythmia syndromes using mouse and human disease models Brugada syndrome, Long QT syndrome Arrhythmogenic cardiomyopathy (ACM) To develop novel therapeutic strategies for preventing (inherited) arrhythmias and sudden cardiac death

Focus of research group (II) Current expertise: Basic and translational electrophysiology In vivo/whole heart electrophysiology (ECG, optical/electrical mapping, arrhythmia inducibility) Cellular electrophysiology (patch clamp, calcium fluorescence) Histology, immunofluorescence, molecular analyses Disease models: transgenic mice, human iPSC-derived cardiomyocytes, human atrial cardiomyocytes (AF) Current funding NWO-VIDI (Carol Ann Remme) CVON-eDETECT (Carol Ann Remme, WP leader) CVON-PREDICT2 (Carol Ann Remme, WP leader, start 1-1-2019) FONDATION LEDUCQ (Connie Bezzina, Carol Ann Remme) ACS Out of the Box (Carol Ann Remme, Diederik Kuster) AMC Foundation (Carol Ann Remme, start 1-1-2019) ZonMw Off Road (Vincent Portero, start 1-1-2019)

Future plans Short term (1-2 year) plan Plan: Functional studies of newly identified genes and disease mechanisms (e.g. microtubule network, metabolic pathways) Necessary infrastructure: Larger scale hiPSC facilities Imaging techniques Medium-throughput electrophysiology (Multi Electrode Array) Long term (>2 year) plan Establish (non-)genetic modifiers of arrhythmia risk Identify and test new arrhythmia mechanisms and therapies Necessary infrastructure (in addition): Larger scale mouse electrophysiological phenotyping facilities High-throughput electrophysiology (automated patch clamp) Collaboration in ACS Connie Bezzina, Arthur Wilde, Joris de Groot, Arie Verkerk, Vivian de Waard, Diederik Kuster