به نام خالق زیبایی ها Hormone 2 Dr.Radmanesh
Pituitary Gland and Hypothalamus
Downloaded from: StudentConsult (on 15 June 2006 06:30 AM) © 2005 Elsevier
Anterior Pituitary continued 11-40
Downloaded from: StudentConsult (on 15 June 2006 06:30 AM) © 2005 Elsevier
Anterior Pituitary 11-37
Downloaded from: StudentConsult (on 15 June 2006 06:30 AM) © 2005 Elsevier
dr. Radmanesh
Hypothalamus, Posterior Pituitary and Target Tissues
Control of ADH Secretion
Action : V1 receptor: constriction of blood vessel increase in blood pressure. V2 receptor: reabsorption of H2O from collecting duct. Dehydration, hemorrhage:↑ADH dr. Radmanesh
Dr. Bolliger Kanas University Medical Center 1999 The basic feedback loop is shown in this slide. An increase in ECF osmolality stimulates the osmoreceptive cells in the two hypothalmic nuclei. The cell bodies of these neurons respond to stretch and their firing rate is directly proportional to it. As we will see soon, these neuroendocrine cells are also innervated by nerve tracks coming from the medulla. These nerve tracks receive input from the baroreceptors in and around the great vessels of the heart. When firing rate of the neuroendocrine cells increase, ADH is released from the post synaptic nerve terminals in the posteriour pituitary. The half life of ADH is only about 20 min. This allows the effect of the hormone to be rapidly present and rapidly cease when it is no longer needed. This is a very tightly regulated hormone. The figure implies that ADH acts on the CCD and Medullary collecting ducts to increase water reaborption. As ADH levels increase, urine volume decreases and urine osmolality increases. http://www2.kumc.edu/ki/physiology/course/six/6_1.htm Dr. Bolliger Kanas University Medical Center 1999 dr. Radmanesh
The Effects of ADH on the distal collecting tubules and Collecting Ducts dr. Radmanesh Figure 26.15a, b
Formation of Water Pores: Mechanism of Vasopressin Action dr. Radmanesh
Facultative water reabsorption dr. Radmanesh
dr. Radmanesh
Control of Oxytocin Secretion
Fig 11.13 11-44
Metabolic Action of Growth Hormone Figure 16.6
Regulation of GH Secretion
Feedback Control of Anterior Pituitary Fig 11.17 11-41