Maya Srivastava, Antonio Perez–Atayde, Maureen M. Jonas

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Presentation transcript:

Drug-associated acute-onset vanishing bile duct and Stevens–Johnson syndromes in a child Maya Srivastava, Antonio Perez–Atayde, Maureen M. Jonas Gastroenterology Volume 115, Issue 3, Pages 743-746 (September 1998) DOI: 10.1016/S0016-5085(98)70154-4 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Liver biopsy at day 45 of cholestasis. (A) There is expansion of the portal tract with edema; a predominantly lymphocytic, mixed inflammatory infiltrate; absence of interlobular bile ducts; and prominent cholangioles (H&E). (B) Cholangioles, indicated by arrows, appear prominent with marked vacuolization of the epithelial lining cells (H&E). (C) Cytokeratin 19 immunohistochemical staining (AE1) shows absence of interlobular bile ducts and abnormal staining of damaged cholangiolar epithelium (arrows). (D) Higher magnification of cytokeratin 19 immunohistochemical stained cholangiolar epithelium (between arrows) shows marked cytoplasmic vacuolization indicative of persistent cholestasis. Gastroenterology 1998 115, 743-746DOI: (10.1016/S0016-5085(98)70154-4) Copyright © 1998 American Gastroenterological Association Terms and Conditions