Wegener's Granulomatosis in a Patient with Fever of Unknown Origin

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Presentation transcript:

Wegener's Granulomatosis in a Patient with Fever of Unknown Origin Harsh C. Patel, MD, Stephen D. Sisson, MD, Naudia N. Lauder, MD The American Journal of Medicine Volume 125, Issue 7, Pages e1-e2 (July 2012) DOI: 10.1016/j.amjmed.2012.02.012 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Renal biopsy. Periodic acid-Schiff methenamine silver stain (top) showing diffuse necrotizing pauci-immune (immunofluorescence-negative) glomerulonephritis with an early cellular crescent. Hematoxylin-eosin stain (bottom) showing acute interstitial nephritis and focal tubulitis with hemorrhage resulting in severe injury and necrosis. These findings are consistent with a vasculitis process, which in the presence of cytoplasmic antineutrophil cytoplasmic antibodies is suggestive of Wegener's granulomatosis. The American Journal of Medicine 2012 125, e1-e2DOI: (10.1016/j.amjmed.2012.02.012) Copyright © 2012 Elsevier Inc. Terms and Conditions