A pilot trial of treprostinil for the treatment and prevention of digital ulcers in patients with systemic sclerosis Lorinda Chung, MD, David Fiorentino,

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Presentation transcript:

A pilot trial of treprostinil for the treatment and prevention of digital ulcers in patients with systemic sclerosis Lorinda Chung, MD, David Fiorentino, MD, PhD Journal of the American Academy of Dermatology Volume 54, Issue 5, Pages 880-882 (May 2006) DOI: 10.1016/j.jaad.2006.02.004 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Improvement of digital ulcers both overlying joints and on digital tips. Clinical photographs of target digital ulcers shown at baseline and after 12 weeks of treprostinil for (A) patient 1 (overlying left fourth fingertip) and (B) patient 2 (overlying right third metacarpal phalangeal joint). Journal of the American Academy of Dermatology 2006 54, 880-882DOI: (10.1016/j.jaad.2006.02.004) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Decrease in size of all digital ulcers. Mean percent change (relative to baseline) in the diameter of ulcers is shown for each subject relative to baseline. Analysis was performed for lesions (A) at digital tips, and (B) overlying joints. Duration of treprostinil therapy is shown with a bar. Journal of the American Academy of Dermatology 2006 54, 880-882DOI: (10.1016/j.jaad.2006.02.004) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions