Effect of dorsal rhizotomy on CaV2

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Effect of dorsal rhizotomy on CaV2 Effect of dorsal rhizotomy on CaV2.2_HA distribution in the dorsal horn. Effect of dorsal rhizotomy on CaV2.2_HA distribution in the dorsal horn. (A) Diagram of the position of dorsal rhizotomy (Left) and central ROIs in the dorsal horn, ipsilateral (ipsi; red) and contralateral (contra; black) to rhizotomy (Right). (B) Images for CaV2.2_HA (green; Left) and CGRP (red; Middle) from a CaV2.2_HAKI/KI mouse following rhizotomy (asterisks). Merged image (Right). (C) Plot profile of CaV2.2_HA fluorescence intensity (mean ± SEM of 15 sections, normalized to the average contralateral intensity between 10 and 50 μm) in dorsal horn ROIs, contralateral (black) and ipsilateral (red) to rhizotomy. (D) Scatter plots of CaV2.2_HA intensity (with blue mean ± SEM) for data from C, in superficial laminae I and II and in laminae III to V, contralateral (black circles) and ipsilateral (red circles) to rhizotomy. ****P < 0.0001, *P = 0.014 (paired t test). (E) Plot profile of CGRP intensity (mean ± SEM of 15 sections, normalized to the average contralateral intensity between 4 and 24 μm) in dorsal horn ROIs, contralateral (black line) and ipsilateral (red line) to rhizotomy. (F) Scatter plots of CGRP intensity (with blue mean ± SEM) for data from E, in superficial laminae I and II and in laminae III to V, contralateral (black circles) and ipsilateral (red circles) to rhizotomy. ****P < 0.0001 (paired t test). Manuela Nieto-Rostro et al. PNAS doi:10.1073/pnas.1811212115 ©2018 by National Academy of Sciences