International Journal of Cardiology

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International Journal of Cardiology Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, Dovilė Karčiauskaitė, Pranas Šerpytis, Virginija Grabauskienė, Dittmar Labeit, Siegfried Labeit International Journal of Cardiology Volume 212, Pages 232-234 (June 2016) DOI: 10.1016/j.ijcard.2016.03.045 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 Heart-specific N2B fragment of titin is a sensitive serological marker for cardiomyocyte injury in MI. A. Distribution of N2B serum levels in STEMI, NSTEMI patients and control sera. A one-way ANOVA revealed significant differences between groups (p-value<0.001) and post hoc comparisons using the Tukey post hoc test revealed that STEMI and NSTEMI had significantly higher serum N2B levels than control sera. B. ROC curve for the developed assay. Serum N2B levels can be used as a sensitive and specific tool in diagnosing MI. C. Dynamics of N2B and TnI biomarkers. Measured biomarker values were plotted against the transformed time from onset of symptoms. Smoothing line for each maker was drawn to emphasise the differences in temporal dynamics of studied biomarkers. Note the time-independent nature of N2B levels in MI patients, in contrast to the single peak shaped distribution profile of TnI levels. D. Comparison of assay sensitivity in early and late detection of MI. Patient sera were divided into early (< 6h) and late (> 6h) MI samples according the time from the reported onset of symptoms and classified as positive or negative, based on the reference values for the MI diagnosis (either manufacturer reported MI rule-in criteria or 99th percentile of healthy population). N2B has comparable sensitivity to hsTnT in early MI diagnosis, and outperforms this assay in late diagnosis (explanations in text). International Journal of Cardiology 2016 212, 232-234DOI: (10.1016/j.ijcard.2016.03.045) Copyright © 2016 The Authors Terms and Conditions