The relationship between dorsal horn neurotransmitter content and allodynia in neuropathic rats treated with high-frequency transcutaneous electric nerve.

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The relationship between dorsal horn neurotransmitter content and allodynia in neuropathic rats treated with high-frequency transcutaneous electric nerve stimulation1 David L Somers, PhD, F.Richard Clemente, PhD Archives of Physical Medicine and Rehabilitation Volume 84, Issue 11, Pages 1575-1583 (November 2003) DOI: 10.1053/S0003-9993(03)00290-9

Fig 1 (A) Mechanical and (B) thermal pain thresholds in the left paws of rats with chronic constriction injury (CCI) that were or were not treated with TENS. Bars are the mean ± standard error of the mean (SEM) 50% withdrawal threshold (WT) for mechanical pain threshold and withdrawal latency (WL) for thermal pain threshold. The thermal pain threshold in rats with chronic constriction injury was reduced at day 12 compared with baseline measurement 1 but was not reduced when compared with baseline measurement 2 (single-factor, repeated-measures ANOVA, Scheffé post hoc comparisons; P≤.05). ∗Significant difference from 1 of the 2 baseline measurements. Archives of Physical Medicine and Rehabilitation 2003 84, 1575-1583DOI: (10.1053/S0003-9993(03)00290-9)

Fig 2 Mechanical and thermal allodynia in the right paw. Bars represent mean ± SEM normalized 50% withdrawal threshold from calibrated Semmes-Weinstein monofilaments in grams (left) and mean ± SEM normalized withdrawal latency from a radiant heat source in seconds (right). The more negative a mean value, the greater the reduction in thermal or mechanical pain threshold. ∗Significant difference from naive control rats (single-factor ANOVA, Scheffé post hoc comparisons; P≤.05). Rats with chronic constriction injury that were treated or not treated with TENS did not differ in normalized pain thresholds. Abbreviation: CO, controls. Archives of Physical Medicine and Rehabilitation 2003 84, 1575-1583DOI: (10.1053/S0003-9993(03)00290-9)

Fig 3 Dorsal horn, synaptosomal content of amino acid neurotransmitters. A 2-factor ANOVA showed a significant effect for group, but not for side of the rat or interaction between group and the side of the rat. Therefore, bars represent the mean synaptosomal content ± SEM (pmol/mg wet weight) for (A) excitatory amino acids and (B) inhibitory amino acids when right and left dorsal horns were averaged together. ∗Significant difference from control rats; †significant difference from rats with chronic constriction injury (single-factor ANOVA, Scheffé post hoc comparisons; P≤.05). Archives of Physical Medicine and Rehabilitation 2003 84, 1575-1583DOI: (10.1053/S0003-9993(03)00290-9)