Aging-related inflammation in osteoarthritis

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General Information Osteoarthritis and Cartilage

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Aging-related inflammation in osteoarthritis M.A. Greene, R.F. Loeser Osteoarthritis and Cartilage Volume 23, Issue 11, Pages 1966-1971 (November 2015) DOI: 10.1016/j.joca.2015.01.008 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Potential age-related changes that increase systemic and local inflammation and promote the development of OA. Systemic levels of multiple pro-inflammatory mediators, in particular IL-6 and TNF-α, increase with age due to production by adipose tissue which becomes more inflammatory with age and due to a chronic low-grade pro-inflammatory state that has been termed “inflamm-aging”. Local changes within the joint have been associated with increased production of inflammatory mediators as has cell senescence through development of the SASP. Osteoarthritis and Cartilage 2015 23, 1966-1971DOI: (10.1016/j.joca.2015.01.008) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions