Validation of EncephalApp, Smartphone-Based Stroop Test, for the Diagnosis of Covert Hepatic Encephalopathy Jasmohan S. Bajaj, Douglas M. Heuman, Richard.

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Validation of EncephalApp, Smartphone-Based Stroop Test, for the Diagnosis of Covert Hepatic Encephalopathy Jasmohan S. Bajaj, Douglas M. Heuman, Richard K. Sterling, Arun J. Sanyal, Muhammad Siddiqui, Scott Matherly, Velimir Luketic, R. Todd Stravitz, Michael Fuchs, Leroy R. Thacker, HoChong Gilles, Melanie B. White, Ariel Unser, James Hovermale, Edith Gavis, Nicole A. Noble, James B. Wade Clinical Gastroenterology and Hepatology Volume 13, Issue 10, Pages 1828-1835.e1 (October 2015) DOI: 10.1016/j.cgh.2014.05.011 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 Comparison of OffTime+OnTime between groups. CHE on paper-pencil tests. Mean ± 95% confidence interval depicted in the bars. (A) Significantly higher OffTime+OnTime in patients with CHE than those without CHE in entire cirrhosis (Cirr) group compared with controls. (B) Significantly higher OffTime+OnTime in patients with CHE than those without CHE in patient group without prior OHE compared with controls. (C) Significantly higher OffTime+OnTime in subjects ≥45 years compared with those <45 years in both control and patient groups. Ctrl, controls. Clinical Gastroenterology and Hepatology 2015 13, 1828-1835.e1DOI: (10.1016/j.cgh.2014.05.011) Copyright © 2015 AGA Institute Terms and Conditions

Figure 2 ROC analysis of OffTime+OnTime against paper-pencil tests. (A) In all patients (AUC, 0.91); (B) in patients without prior OHE (AUC, 0.88). Clinical Gastroenterology and Hepatology 2015 13, 1828-1835.e1DOI: (10.1016/j.cgh.2014.05.011) Copyright © 2015 AGA Institute Terms and Conditions

Figure 3 Change in EncephalApp results with TIPS and hyponatremia correction. (A) OffTime+OnTime before/after TIPS placement. (B) OffTime+OnTime before/after hyponatremia correction. Clinical Gastroenterology and Hepatology 2015 13, 1828-1835.e1DOI: (10.1016/j.cgh.2014.05.011) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 1 Correlation of OffTime+OnTime results on repeat testing. Clinical Gastroenterology and Hepatology 2015 13, 1828-1835.e1DOI: (10.1016/j.cgh.2014.05.011) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 2 Correlation of iPod and iPad OffTime+OnTime results of EncephalApp. Clinical Gastroenterology and Hepatology 2015 13, 1828-1835.e1DOI: (10.1016/j.cgh.2014.05.011) Copyright © 2015 AGA Institute Terms and Conditions