An in vivo Large Animal Model to Study Impact-induced Cartilage Injury and the Development of Early Posttraumatic Ankle Osteoarthritis M.L. Delco, E.D.

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Presentation transcript:

An in vivo Large Animal Model to Study Impact-induced Cartilage Injury and the Development of Early Posttraumatic Ankle Osteoarthritis M.L. Delco, E.D. Bonnevie, P.G. Alexander, R.S. Tuan, L.J. Bonassar, L.A. Fortier Osteoarthritis and Cartilage Volume 25, Pages S309-S310 (April 2017) DOI: 10.1016/j.joca.2017.02.519 Copyright © 2017 Terms and Conditions

Fig. 1. Ex vivo and in vivo model development Fig. 1. Ex vivo and in vivo model development. A) Spring-loaded impactor instrumented with internal load cell to measure force (F) and a linear variable displacement transducer (LVDT) to measure displacement, 2 impact tips (s and L; inset) B) Impact F was converted to stress using impact area measured on pressure sensitive paper to determine relationship between F and stress. C) Impacts were applied to tali in areas (4 & 6) of highest incidence of osteochondral lesions in humans. D) Arthroscopic view of impacts (arrows) on the medial trochlea of the talus. Small impact tip (star) within joint. E) Post mortem; India ink marks impacts (arrow heads). Osteoarthritis and Cartilage 2017 25, S309-S310DOI: (10.1016/j.joca.2017.02.519) Copyright © 2017 Terms and Conditions