SATB1 Is a Pivotal Epigenetic Biomarker in Cutaneous T-Cell Lymphomas Sandrine Poglio, Jean-Philippe Merlio  Journal of Investigative Dermatology  Volume 138, Issue 8, Pages 1694-1696 (August 2018) DOI: 10.1016/j.jid.2018.04.018 Copyright © 2018 The Authors Terms and Conditions

Figure 1 Schematic representation of SATB1 regulation and functions in normal human/murine CD4+ T cells, mycosis fungoides, and cutaneous anaplastic large cell lymphoma. (a) In mouse T cells, SATB1 activates expression of Th2 cytokines after TCR activation (Gottimukkala et al., 2016; Hwang et al., 2017). (b) In normal human T cells, TCR and IL-4 activation increase SATB1 expression, which inhibits Th2 cytokine expression (Ahlfors et al., 2010; Lund et al., 2005). (c) In mycosis fungoides cells, SATB1 expression is negatively regulated by the activation of the Jak3/Stat5 pathway through miR-155 (Fredholm et al., 2018). (d) In cutaneous anaplastic large cell lymphoma, SATB1 is expressed after promoter demethylation, which is associated with Th17 polarization (Sun et al. 2018). miR, micro RNA; Th, T helper. Journal of Investigative Dermatology 2018 138, 1694-1696DOI: (10.1016/j.jid.2018.04.018) Copyright © 2018 The Authors Terms and Conditions