John W. Steinke, PhD, Spencer C. Payne, MD, M

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Presentation transcript:

Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis John W. Steinke, PhD, Spencer C. Payne, MD, M. Elizabeth Tessier, MD, Lori O. Borish, RN, Joseph K. Han, MD, Larry C. Borish, MD Journal of Allergy and Clinical Immunology Volume 124, Issue 6, Pages 1352-1354.e7 (December 2009) DOI: 10.1016/j.jaci.2009.09.018 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Change in CT score after budesonide nasal irrigation. Each dot represents an individual with a line connecting the prebudesonide and postbudesonide CT scores. The bold lines to the side of the data points indicate the median, with the interquartile range and inner fence indicated with a box and whisker plot, respectively (P < .05 for prebudesonide compared with postbudesonide sinus score). Journal of Allergy and Clinical Immunology 2009 124, 1352-1354.e7DOI: (10.1016/j.jaci.2009.09.018) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Self-assessed change in sinus symptom score after budesonide nasal irrigation. Each dot represents an individual, with a line connecting the prebudesonide and postbudesonide sinus scores. Lines to the side of the data points indicate the mean ± SEM (P < .01 for prebudesonide compared with postbudesonide sinus score). Journal of Allergy and Clinical Immunology 2009 124, 1352-1354.e7DOI: (10.1016/j.jaci.2009.09.018) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

VAS for sinus symptoms. Each subject was asked to rate each of 16 symptoms. The range of symptoms was none to severe. Journal of Allergy and Clinical Immunology 2009 124, 1352-1354.e7DOI: (10.1016/j.jaci.2009.09.018) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Patient perception of sense of smell after budesonide nasal irrigation Patient perception of sense of smell after budesonide nasal irrigation. Using a VAS, subjects were asked to assess their sense of smell before and after nasal irrigation. The VAS was converted to a digital scale rated 0 (no smell) to 6 (no impairment in ability to smell). Each dot represents an individual with a line connecting the prebudesonide and postbudesonide scores, and the lines to the side of the data points indicate the means ± SEMs (P <.05 for prebudesonide compared with postbudesonide sense of smell). Journal of Allergy and Clinical Immunology 2009 124, 1352-1354.e7DOI: (10.1016/j.jaci.2009.09.018) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Endoscopic scoring system. Modified from Lund VJ, Kennedy DW Endoscopic scoring system. Modified from Lund VJ, Kennedy DW. Staging for rhinosinusitis. Otolaryngol Head Neck Surg 1997;117:S35-S40.E7 Journal of Allergy and Clinical Immunology 2009 124, 1352-1354.e7DOI: (10.1016/j.jaci.2009.09.018) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

VAS for asthma symptoms VAS for asthma symptoms. Each subject was asked to rate each of 6 symptoms. Journal of Allergy and Clinical Immunology 2009 124, 1352-1354.e7DOI: (10.1016/j.jaci.2009.09.018) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions