PDE5 inhibitor sildenafil in the treatment of heart failure: A meta-analysis of randomized controlled trials  Xiao-Dong Zhuang, Ming Long, Fei Li, Xun.

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PDE5 inhibitor sildenafil in the treatment of heart failure: A meta-analysis of randomized controlled trials  Xiao-Dong Zhuang, Ming Long, Fei Li, Xun Hu, Xin-Xue Liao, Zhi-Min Du  International Journal of Cardiology  Volume 172, Issue 3, Pages 581-587 (April 2014) DOI: 10.1016/j.ijcard.2014.01.102 Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Flow diagram of the study selection process. International Journal of Cardiology 2014 172, 581-587DOI: (10.1016/j.ijcard.2014.01.102) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Pooled relative risk and mean difference in the outcome of advance events (A), 12-month peak VO2 (B) in the substudies considering sildenafil compared to placebo therapy between EFrHF and EFpHF patients. International Journal of Cardiology 2014 172, 581-587DOI: (10.1016/j.ijcard.2014.01.102) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Pooled mean difference in the outcome of VO2 at AT (A), VE/CO2 slope (B), LV ejection fraction (C) in the studies considering sildenafil compared to placebo therapy in HF patients. International Journal of Cardiology 2014 172, 581-587DOI: (10.1016/j.ijcard.2014.01.102) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Pooled mean differences in the outcome of heart rate (A), systolic blood pressure (B), diastolic blood pressure (C) and pulmonary systolic pressure (D) in the studies considering sildenafil compared to placebo therapy in HF patients. International Journal of Cardiology 2014 172, 581-587DOI: (10.1016/j.ijcard.2014.01.102) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Pooled mean difference in the outcome of emotional function (A), fatigue (B), and breathlessness (C) in the studies considering sildenafil compared to placebo therapy in HF patients. International Journal of Cardiology 2014 172, 581-587DOI: (10.1016/j.ijcard.2014.01.102) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

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