(A) Rexed laminae of the spinal cord.

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(A) Rexed laminae of the spinal cord. (A) Rexed laminae of the spinal cord. Laminae I and II form the marginal zone and substantia gelatinosa, respectively, and together these make up the superficial dorsal horn. Within the dorsal horn, Aβ tactile and hair afferents end mainly in laminae III–VI with some extension into lamina IIi with distribution dependent on function. Aδ hair-follicle afferents extend across the lamina II/III border. Aδ nociceptors end mainly in lamina I, occasionally branching to laminae V and X. Peptidergic, nociceptive C fiber afferents synapse mainly in lamina I and IIo. Nonpeptidergic C fibers occupy the inner part of lamina II. (B) Acutely isolated spinal cord slice from a 30-day-old rat. The substantia gelatinosa is clearly visible as a translucent band under infrared differential interference contrast optics. (C) Diagram to illustrate the principal synaptic connections in the superficial dorsal horn. From Peirs and Seal (2016). Reprinted with permission from American Association for the Advancement of Science. Sascha R. A. Alles, and Peter A. Smith Pharmacol Rev 2018;70:315-347 Copyright © 2018 by The Author(s)‏