J. Zhang, X. -F. Zhang, C. Zhou, Z. -Z. Wang, S. -J. Huang, X. Yao, Z

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Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity J. Zhang, X.-F. Zhang, C. Zhou, Z.-Z. Wang, S.-J. Huang, X. Yao, Z.-L. Liang, T. Wu, J.-X. Li, Q. Yan, C.-L. Yang, H.-M. Jiang, H.-J. Huang, Y.-L. Xian, J. W.-K. Shih, M.-H. Ng, Y.-M. Li, J.-Z. Wang, F.-C. Zhu, N.-S. Xia Clinical Microbiology and Infection Volume 20, Issue 6, Pages O397-O405 (June 2014) DOI: 10.1111/1469-0691.12419 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Analytical cohorts. Clinical Microbiology and Infection 2014 20, O397-O405DOI: (10.1111/1469-0691.12419) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 The anti-hepatitis E virus (HEV) IgG status of cohorts, (a) Pre-vaccination anti-HEV IgG prevalence among different age groups, (b) Geometric mean concentration (GMC) of seropositive subjects in the per-protocol cohort, (c) Anti-HEV IgG prevalence of vaccine and placebo groups and (d) the GMC, among the seropositive subjects of the respective groups, before and at different months after the first dose. Clinical Microbiology and Infection 2014 20, O397-O405DOI: (10.1111/1469-0691.12419) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 Anti-hepatitis E virus (HEV) IgG serological events after vaccination. (a) and (b) compare the IgG antibody levels of the first (<x-axis) and the second (<y-axis) of the paired serum samples obtained from subjects in the placebo (a) and vaccine (b) groups of the per-protocol infection subset in months 7 and 19 or in months 19 and 31. Arrows indicate three confirmed hepatitis E cases. Percent of men (c) and mean age (d) of those affected by the different serological events identified in (a) and (b) (solid blocks) were compared with the corresponding values of the respective cohorts as a whole (open blocks). Clinical Microbiology and Infection 2014 20, O397-O405DOI: (10.1111/1469-0691.12419) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 4 Anti-hepatitis E virus (HEV) IgG pre- and post-HEV infection. The line within the plots indicates the geometric mean concentration (GMC) of anti-HEV. The GMC value and the sample size of each column are listed above the x-axis. Pre-inf, the latest sample collected before the infection; Asympt-, after asymptomatic infection; Sympt-, after symptomatic infection; Post-inf, the first sample collected after the infection. Clinical Microbiology and Infection 2014 20, O397-O405DOI: (10.1111/1469-0691.12419) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions