Primacy of the 3B Approach to Control Risk Factors for Cardiovascular Disease in Type 2 Diabetes Patients  Linong Ji, MD, Dayi Hu, MD, Changyu Pan, MD, Jianping Weng, MD, Yong Huo, MD, Changsheng Ma, MD, Yiming Mu, MD, Chuanming Hao, MD, Qiuhe Ji, MD, Xingwu Ran, MD, Benli Su, MD, Hanjing Zhuo, MPH, Keith A.A. Fox, MD, Michael Weber, MD, Danyi Zhang, MD  The American Journal of Medicine  Volume 126, Issue 10, Pages 925.e11-925.e22 (October 2013) DOI: 10.1016/j.amjmed.2013.02.035 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Association of cardiovascular risk factors and comorbidity in patients with type 2 diabetes who participated in the 3B STUDY. Some patients had more than one comorbidity. BMI = body mass index; CBD = cerebrovascular disease (including ischemic stroke, hemorrhagic stroke or transient ischemic attack); CVD = cardiovascular disease (including stable angina, unstable angina, myocardial infarction, percutaneous coronary intervention, or underwent coronary bypass); T2D = type 2 diabetes; T2D+DYLP = type 2 diabetes with comorbid dyslipidemia; T2D+HTN = type 2 diabetes with comorbid hypertension; T2D+HTN+DYLP = type 2 diabetes with both comorbid hypertension and dyslipidemia. The American Journal of Medicine 2013 126, 925.e11-925.e22DOI: (10.1016/j.amjmed.2013.02.035) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Independent factors that may predict or influence the control of cardiovascular risk factors (HbA1c <7.0%, TC <4.5 mmol/L, and BP <130/80 mm Hg) in patients with Type 2 diabetes who participated in the 3B STUDY. (A) Independent predictors for HbA1c <7.0%. (B) Independent predictors for HbA1c <7.0% and BP <130/80 mm Hg. (C) Independent predictors for HbA1c <7.0% and TC <4.5 mmol/L. (D) Independent predictors for all targets (HbA1c <7.0%, TC <4.5 mmol/L, and BP <130/80 mm Hg) met.Abbreviations: BP = blood pressure; CI = confidence interval; HbA1c = glycosylated hemoglobin; OR = odds ratio; TC = total serum cholesterol. Adjusted OR with their 95% CIs are reported from the final models. Variables in the full multivariate model for each dependent variable included: age, sex, body mass index, education level, medical insurance, personal income, smoking, alcohol consumption, physical activities, duration of diabetes, hospital tier, and physician specialty. Age, body mass index, and diabetes are converted to categorical variables. The American Journal of Medicine 2013 126, 925.e11-925.e22DOI: (10.1016/j.amjmed.2013.02.035) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Independent factors that may predict or influence the control of cardiovascular risk factors (HbA1c <7.0%, TC <4.5 mmol/L, and BP <130/80 mm Hg) in patients with Type 2 diabetes who participated in the 3B STUDY. (A) Independent predictors for HbA1c <7.0%. (B) Independent predictors for HbA1c <7.0% and BP <130/80 mm Hg. (C) Independent predictors for HbA1c <7.0% and TC <4.5 mmol/L. (D) Independent predictors for all targets (HbA1c <7.0%, TC <4.5 mmol/L, and BP <130/80 mm Hg) met.Abbreviations: BP = blood pressure; CI = confidence interval; HbA1c = glycosylated hemoglobin; OR = odds ratio; TC = total serum cholesterol. Adjusted OR with their 95% CIs are reported from the final models. Variables in the full multivariate model for each dependent variable included: age, sex, body mass index, education level, medical insurance, personal income, smoking, alcohol consumption, physical activities, duration of diabetes, hospital tier, and physician specialty. Age, body mass index, and diabetes are converted to categorical variables. The American Journal of Medicine 2013 126, 925.e11-925.e22DOI: (10.1016/j.amjmed.2013.02.035) Copyright © 2013 Elsevier Inc. Terms and Conditions