Better preservation of endothelial function and decreased activation of the fetal renin- angiotensin pathway with the use of pulsatile flow during experimental.

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Presentation transcript:

Better preservation of endothelial function and decreased activation of the fetal renin- angiotensin pathway with the use of pulsatile flow during experimental fetal bypass Catherine Vedrinne, MDa, François Tronc, MDb, Stéphane Martinot, MVDc, Jacques Robin, MDb, Anne-Marie Allevard, PhDd, Madeleine Vincent, PhDd, Jean Jacques Lehot, MDa, Michel Franck, MVDc, Gérard Champsaur, MDb The Journal of Thoracic and Cardiovascular Surgery Volume 120, Issue 4, Pages 770-777 (October 2000) DOI: 10.1067/mtc.2000.108902 Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Fetal plasma level of lactate (mmol · L–1): Measurements were made after fetal exteriorization, on bypass, and at the end of bypass. Black circle, Within-group differences, P < .05. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 770-777DOI: (10.1067/mtc.2000.108902) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Mean pump flow evolution (mL · min–1 · kg–1) and between-group comparison. T10, 10 minutes of bypass; T60, 60 minutes of bypass. *Intergroup differences, pulsatile-flow versus steady-flow group; P < .05. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 770-777DOI: (10.1067/mtc.2000.108902) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Mean distal aortic flow evolution (mL · min–1 · kg–1) and between-group comparison. Tb, Baseline time; Tc, cannulation time; T10 to T60, every 10 minutes after initiation of bypass. *Intergroup differences, pulsatile-flow versus steady-flow group; P < .05. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 770-777DOI: (10.1067/mtc.2000.108902) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Mean umbilical flow evolution (mL · min–1 · kg–1) and between-group comparison. Tb, Baseline time; Tc, cannulation time; T10 to T60, every 10 minutes after initiation of bypass. *Intergroup differences, pulsatile-flow versus steady-flow group; P < .05. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 770-777DOI: (10.1067/mtc.2000.108902) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Mean fetal systemic vascular resistances evolution (mm Hg · mL–1 · min–1 · kg–1) and between-group comparison. T10, 10 minutes of bypass; T60, 60 minutes of bypass. *Intergroup differences, pulsatile-flow versus steady-flow group; P < .05. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 770-777DOI: (10.1067/mtc.2000.108902) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 Mean placental vascular resistances evolution (mm Hg · mL–1 · min–1 · kg–1) and between-group comparison. Tb, Baseline time; Tc, cannulation time; T10 to T60, every 10 minutes after initiation of bypass. *Intergroup differences, pulsatile-flow versus steady-flow group; P < .05. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 770-777DOI: (10.1067/mtc.2000.108902) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions