Silent Synapses Sit and Wait for a Better Day

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Presentation transcript:

Silent Synapses Sit and Wait for a Better Day Darwin K. Berg Neuron Volume 61, Issue 2, Pages 157-159 (January 2009) DOI: 10.1016/j.neuron.2009.01.004 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Showing the Dependence of CHT Expression on Synaptic Transmission ACh, released from the preganglionic terminal, activates postsynaptic α3-nAChRs to generate (possibly via depolarization, Vm) a retrograde-acting signal that crosses the synapse and is relayed back up the preganglionic axon to the nucleus where it stimulates CHT expression. The newly synthesized CHT is incorporated into synaptic vesicle membrane, transported to the presynaptic terminal, and transferred to the surface by vesicle exocytosis. On the surface, CHT recovers choline into the terminal, thereby supporting the rapid resynthesis of ACh required to sustain high-frequency transmission at the synapses. Neuron 2009 61, 157-159DOI: (10.1016/j.neuron.2009.01.004) Copyright © 2009 Elsevier Inc. Terms and Conditions