Effect of l-arginine or nitroglycerine during deep hypothermic circulatory arrest in neonatal lambs Shinichi Hatsuoka, MD, Takahiko Sakamoto, MD, Ulrich.

Slides:

Advertisements

Similar presentations

Leena Khaitan, MD, Francis P Sutter, Scott M Goldman, MD

Advertisements

Oral Sildenafil Reduces Pulmonary Hypertension After Cardiac Surgery

Effect of a Single Bolus of Erythropoietin on Renoprotection in Patients Undergoing Thoracic Aortic Surgery With Moderate Hypothermic Circulatory Arrest

Revascularization of severe hibernating myocardium in the beating heart: early hemodynamic and metabolic features Evasio Pasini, MD, Gianna Ferrari,

Kai Ihnken, MD, Kiyozo Morita, MD, Gerald D Buckberg, MD

Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester Takeshi Hiramatsu,

Regional low-flow perfusion provides somatic circulatory support during neonatal aortic arch surgery Frank A Pigula, MD, Sanjiv K Gandhi, MD, Ralph D.

Sodium nitroprusside mitigates oleic acid-induced acute lung injury

Should We Ablate Atrial Fibrillation During Coronary Artery Bypass Grafting and Aortic Valve Replacement? Talal Al-Atassi, MD, MPH, Donna-May Kimmaliardjuk,

Management of catheter-induced pulmonary artery perforation: a rare complication in cardiovascular operations Srikrishna Sirivella, MD, Isaac Gielchinsky,

Effect of hemofiltrated whole blood pump priming on hemodynamics and respiratory function after the arterial switch operation in neonates Mitsugi Nagashima,

Cardiac performance after deep hypothermic circulatory arrest in chronically cyanotic neonatal lambs Mitsugi Nagashima, MDa, Georg Nollert, MDa, Ulrich.

Continuous pulmonary perfusion during cardiopulmonary bypass prevents lung injury in infants Takaaki Suzuki, MD, Toyoki Fukuda, MD, Tsutomu Ito, MD,

The role of cardioplegia induction temperature and amino acid enrichment in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD,

Effect of perfusion flow rate on tissue oxygenation in newborn piglets during cardiopulmonary bypass Gregory Schears, MD, Steven E Schultz, MD, Jennifer.

Lung transplantation for primary and secondary pulmonary hypertension

Sivelestat Attenuates Lung Injury in Surgery for Congenital Heart Disease With Pulmonary Hypertension Norikazu Nomura, MD, PhD, Miki Asano, MD, PhD,

Steven R. Gundry, MD, Matthew A. Romano, MD, O

Effects of Depletion of Leukocytes and Platelets on Cardiac Dysfunction After Cardiopulmonary Bypass Yukio Chiba, Kouichi Morioka, Ryusuke Muraoka, Akio.

Comparison of neurologic outcome after deep hypothermic circulatory arrest with alpha- stat and pH-stat cardiopulmonary bypass in newborn pigs Margaret.

ECMO and Inhaled Nitric Oxide for Cardiopulmonary Failure After Heart Retransplantation Nicoletta Barzaghi, MD, Maddalena Olivei, MD, Gaetano Minzioni,

Decreased exhaled nitric oxide may be a marker of cardiopulmonary bypass–induced injury Maurice Beghetti, MD, Philip E Silkoff, Marlova Caramori, MD,

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

The influence of leukocyte filtration during cardiopulmonary bypass on postoperative lung function: A clinical study Tomislav Mihaljevic, MDa, Martin.

Synergistic Immunosuppression Caused by High-Dose Methylprednisolone and Cardiopulmonary Bypass Hisanori Mayumi, MD, Qui-Wei Zhang, MD, Atsuhiro Nakashima,

An Analysis of Oxygen Consumption and Oxygen Delivery in Euthermic Infants After Cardiopulmonary Bypass With Modified Ultrafiltration Jia Li, MD, PhD,

Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts Jeffrey M Pearl, MD, David P Nelson, MD, PhD, Steven M Schwartz,

Effects of Nitric Oxide After Cardiac Transplantation in the Setting of Recipient Pulmonary Hypertension Edward P Chen, MD, Hartmuth B Bittner, MD, PhD,

Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest Elaine E Tseng, MD, Malcolm V Brock, MD, Christopher.

Determination of optimum retrograde cerebral perfusion conditions

Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery John L Francis, PhD, George J Palmer, MD, Rebecca Moroose,

John S. Ikonomidis, MD, PhD, Ebony J

Pulmonary vascular resistance after cardiopulmonary bypass in infants: Effect on postoperative recovery Ingram Schulze-Neick, MDa, Jia Li, MDa, Daniel.

Thomas S. Maxey, MD, Christopher D. Smith, MBBS, John A

Effects of selectin–sialyl Lewisx blockade on mesenteric microvascular permeability associated with cardiopulmonary bypass Charles S. Cox, MD, Steven.

Increasing duration of circulatory arrest, but not antegrade cerebral perfusion, prolongs postoperative recovery after neonatal cardiac surgery Selma.

Perioperative cardiac function and predictors for adverse events after transmyocardial laser treatment Ole Tjomsland, MD, Lars Aaberge, MD, Sven M Almdahl,

Masahiro Ono, MD, PhD, Charles Brown, MD, Jennifer K

Nitecapone as an additive to crystalloid cardioplegia in patients who had coronary artery bypass grafting Antti E Vento, MD, Juha Aittomäki, MD, Kalervo.

Ivan Ricardo Argueta-Morales, MD, Hamish M

Continuous cold blood cardioplegia improves myocardial protection: a prospective randomized study Yves A.G Louagie, MD, PhD, Jacques Jamart, MD, Manuel.

Effects of perfusion mode on regional and global organ blood flow in a neonatal piglet model Akif Ündar, PhD, Takafumi Masai, MD, Shuang-Qiang Yang,

Which is better to preserve pulmonary function: Short-term or prolonged leukocyte depletion during cardiopulmonary bypass? Kaiyu Tao, MD, Qi An, MD,

Editorial Board, January 2010

Anticoagulation with bivalirudin during cardiopulmonary bypass in cardiac surgery Julio C Vasquez, MD, Anna Vichiendilokkul, PharmD, Syed Mahmood, MD,

Platelet and Neutrophil Activation During Cardiac Surgical Procedures: Impact of Cardiopulmonary Bypass David S Morse, David Adams, Barbarajean Magnani

Kai Ihnken, MD The Journal of Thoracic and Cardiovascular Surgery

Drew-Anderson technique attenuates systemic inflammatory response syndrome and improves respiratory function after coronary artery bypass grafting Josef.

Combination of alpha-stat strategy and hemodilution exacerbates neurologic injury in a survival piglet model with deep hypothermic circulatory arrest

Randomized controlled study of inhaled nitric oxide after operation for congenital heart disease Ronald W Day, MD, John A Hawkins, MD, Edwin C McGough,

Nicorandil, a potent adenosine triphosphate–sensitive potassium-channel opener, ameliorates lung allograft reperfusion injury Motohiro Yamashita, MD,

Sialyl LewisX oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs Marc L. Schermerhorn,

Cardiac surgery with deep hypothermic circulatory arrest produces less systemic inflammatory response than low-flow cardiopulmonary bypass in newborns

Nitric Oxide Dose Response During Moderate and Severe Hypoxia in Swine

Nitric oxide mediates fluid accumulation during cardiopulmonary bypass

Effect of cardiopulmonary bypass on pulmonary gas exchange: a prospective randomized study Craig M Cox, Raimondo Ascione, MD, Alan M Cohen, Ian M Davies,

Association of bacterial infection and red blood cell transfusion after coronary artery bypass surgery Scott B Chelemer, MD, B.Stephen Prato, MA, Paul.

Deep hypothermic circulatory arrest during the arterial switch operation is associated with reduction in cerebral oxygen extraction but no increase in.

The limits of detectable cerebral perfusion by transcranial doppler sonography in neonates undergoing deep hypothermic low-flow cardiopulmonary bypass

Inhaled nitric oxide for adult respiratory distress syndrome after pulmonary resection Douglas J Mathisen, MD, Elbert Y Kuo, Chiwon Hahn, MD, Ashby C.

Preoperative Intraaortic Balloon Pump Enhances Cardiac Performance and Improves the Outcome of Redo CABG Jan T. Christenson, MD, PhD, Pierre Badel, MD,

Postbypass effects of delayed rewarming on cerebral blood flow velocities in infants after total circulatory arrest Rosendo A. Rodriguez, MD, PhDa (by.

Aprotinin Enhances the Endogenous Release of Interleukin-10 After Cardiac Operations Gary E Hill, Robert P Diego, Alfred H Stammers, Suzanne M Huffman,

Sunil K. Ohri, Christopher W. Bowles, Robert T. Mathie, David R

Effect of Nitric Oxide Gas on Platelets During Open Heart Operations

B.H. Cuthbertson, S.A. Stott, N.R. Webster

Intratracheal Surfactant Administration Preserves Airway Compliance During Lung Reperfusion Scott A Buchanan, Michael C Mauney, Vikas I Parekh, Nuno.

Michael T. Kronon, MD, Bradley S

Prospective randomized neurocognitive and S-100 study of hypothermic circulatory arrest, retrograde brain perfusion, and antegrade brain perfusion for.

Safety of low hematocrits during cardiopulmonary bypass

Presentation transcript:

Effect of l-arginine or nitroglycerine during deep hypothermic circulatory arrest in neonatal lambs Shinichi Hatsuoka, MD, Takahiko Sakamoto, MD, Ulrich A Stock, MD, Mitsugi Nagashima, MD, John E Mayer, MD The Annals of Thoracic Surgery Volume 75, Issue 1, Pages 197-203 (January 2003) DOI: 10.1016/S0003-4975(02)04335-7

Fig 1 (A) Percentage recovery of preload recruitable stroke work before and after cardiopulmonary bypass (CPB). *p < 0.05 compared with nitroglycerine (TNG) and l-arginine group. #p < 0.05 compared with l-arginine group. (B) Percentage recovery of cardiac index before and after cardiopulmonary bypass *p < 0.05 compared with nitroglycerine and l-arginine groups. The Annals of Thoracic Surgery 2003 75, 197-203DOI: (10.1016/S0003-4975(02)04335-7)

Fig 2 (A) Percentage recovery of pulmonary vascular resistance before and after cardiopulmonary bypass (CPB). *p < 0.05 compared with nitroglycerine (TNG), l-arginine group; #p < 0.05 compared with nitroglycerine group. (B) Recovery of systemic pulmonary pressure/systemic arterial pressure ratio (PAP/SAP) before and after cardiopulmonary bypass. *p < 0.05 compared with nitroglycerine, l-arginine group; #p < 0.05 compared with nitroglycerine group. The Annals of Thoracic Surgery 2003 75, 197-203DOI: (10.1016/S0003-4975(02)04335-7)

Fig 3 (A) Percentage recovery of alveolar−arterial oxygen tension difference before and after cardiopulmonary bypass (CPB). (N.S. = not significant.) (B) Percentage recovery of lung compliance. *p < 0.05 compared with l-arginine group. The Annals of Thoracic Surgery 2003 75, 197-203DOI: (10.1016/S0003-4975(02)04335-7)

Fig 4 Percentage recovery of bioelectric impedance. (CPB = cardiopulmonary bypass; N.S. = not significant; TNG = nitroglycerine.) The Annals of Thoracic Surgery 2003 75, 197-203DOI: (10.1016/S0003-4975(02)04335-7)

Fig 5 (A) Nitric oxide metabolites in the coronary sinus plasma before and after cardiopulmonary bypass. (B) Malondialdehyde (MDA) in heart and lung tissue. (CPB = cardiopulmonary bypass; N.S. = not significant; TNG = nitroglycerine.) The Annals of Thoracic Surgery 2003 75, 197-203DOI: (10.1016/S0003-4975(02)04335-7)

Fig 6 (A) Mitochondrial respiratory chain complex activities. (B) Percentage recovery of oxygen extraction ratio before and after cardiopulmonary bypass (CPB). *p < 0.05 control group vs. l–arginine and vs. TNG. (COX = cytochrome c oxidase; N.S. = not significant; TNG = nitroglycerine.) The Annals of Thoracic Surgery 2003 75, 197-203DOI: (10.1016/S0003-4975(02)04335-7)