Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn.

Slides:

Advertisements

Similar presentations

Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow Patrick E Parrino, MD, Victor E Laubach, PhD, John R.

Advertisements

Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat Ryuzo Bessho, MD, PhD, David J. Chambers,

Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery Manuel Castellá, MD, Gerald D.

Coronary Artery Bypass for Heart Failure in Ischemic Cardiomyopathy: 17-Year Follow- Up Marco Pocar, MD, PhD, Andrea Moneta, MD, Adalberto Grossi, MD,

Therapeutic angiogenesis with intramyocardial administration of basic fibroblast growth factor Michio Kawasuji, MD, Hiroshi Nagamine, MD, Masahiro Ikeda,

Celsior versus custodiol: early postischemic recovery after cardioplegia and ischemia at 5°C Juergen Ackemann, MD, Wolfgang Gross, PhD, Martin Mory,

A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion.

Coronary artery bypass grafting on the beating heart evaluated with integrated backscatter Kenichi Imasaka, MD, Shigeki Morita, MD, Ichiro Nagano, MD,

Revascularization of severe hibernating myocardium in the beating heart: early hemodynamic and metabolic features Evasio Pasini, MD, Gianna Ferrari,

Adenosine-enhanced ischemic preconditioning modulates necrosis and apoptosis: effects of stunning and ischemia–reperfusion Bradford Stadler, BS, Jonathan.

Functional evaluation of human donation after cardiac death donor hearts using a continuous isolated myocardial perfusion technique: Potential for expansion.

Is hyperglycemia bad for the heart during acute ischemia?

Preconditioning protects the severely atherosclerotic mouse heart

Feasibility of a three-axis epicardial accelerometer in detecting myocardial ischemia in cardiac surgical patients Per Steinar Halvorsen, MD, Andreas.

Per Steinar Halvorsen, MD, Espen W

Hyperdynamic circulation of arteriovenous fistula preconditions the heart and limits infarct size Mahmoud A Mahgoub, MD, Jian-Hau Guo, MD, Shi-Ping Gao,

Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia Y.Joseph Woo, MD, Matthew D Taylor, BS,

Ventricular septal rupture caused by myocardial bridging

Calcium-Channel Blockers Preserve Coronary Endothelial Reactivity After Ischemia- Reperfusion François Dagenais, MD, Raymond Cartier, MD, Charleen Hollmann,

The role of cardioplegia induction temperature and amino acid enrichment in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD,

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Effect of modified ultrafiltration in high-risk patients undergoing operations for congenital heart disease1 Ko Bando, MD, Mark W Turrentine, MD, Palaniswamy.

Juan A. Crestanello, MD, Richard C. Daly, MD

Hiroki Sato, James E Jordan, Zhi-Qing Zhao, S

Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury William E. Stansfield,

Prolonged preservation of the blood-perfused canine heart with glycolysis-promoting solution Koh Takeuchi, MD, Hung Cao-Danh, PhD, Akihiko Kawai, MD,

Ninety-degree anterior cardiac displacement in off-pump coronary artery bypass grafting: the Starfish cardiac positioner preserves stroke volume and arterial.

Long-term treatment with nipradilol, a nitric oxide–releasing β-adrenergic blocker, enhances postischemic recovery and limits infarct size Yoshihiro.

Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction Shigetoshi.

Continuous warm versus intermittent cold cardioplegic infusion: A comparison of energy metabolism, sodium-potassium adenosine triphosphatase activity,

Effects of cardioplegia on vascular function and the “no-reflow" phenomenon after ischemia and reperfusion: Studies in the isolated blood-perfused rat.

J. Trent Magruder, MD, Todd C

Maria Kalliopi Konstantinidou, MD, PhD, Neil Moat, MD, PhD

Coronary Microvascular Reactivity After Ischemic Cold Storage and Reperfusion Charles O Murphy, MD, Pan- Chih, MD, John Parker Gott, MD, Robert A Guyton,

Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways Jun Feng, MD, PhD, Eliot R Rosenkranz, MD

Application of cabrol technique to off-pump coronary artery bypass grafting using radial artery Won-Min Jo, MD, Chan-Young Na, MD, PhD, Man-Jong Baek,

Intraoperative evaluation of coronary anastomosis by transit-time ultrasonic flow measurement Tetsuro Morota, MD, PhD, Francis G Duhaylongsod, MD, William.

Single coronary artery and complete transposition of the great arteries: a technical challenge resolved? Vinayak Shukla, Robert M Freedom, MD, Michael.

Organ perfusion with hemopump device assistance with and without intraaortic balloon pumping Bart Meyns, MD, Yousuke Nishimura, MD, Rozalia Racz, MD,

Munir Boodhwani, MD, William E

Morbidity, cost, and six-month outcome of minimally invasive direct coronary artery bypass grafting James A Magovern, MD, Daniel H Benckart, MD, Rodney.

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Ischemic preconditioning with opening of mitochondrial adenosine triphosphate– sensitive potassium channels or Na+/H+ exchange inhibition: Which is the.

Ischemic preconditioning does not improve myocardial preservation during off-pump multivessel coronary operation Hannu J Penttilä, MD, Martti V.K Lepojärvi,

Elimination of Ischemic Mitral Regurgitation Does Not Alter Long-Term Left Ventricular Remodeling in the Ovine Model Kanji Matsuzaki, MD, PhD, Masato.

Ventriculocoronary artery bypass results using a mesh-tipped device in a porcine model Robert W Emery, MD, Frazier Eales, MD, Clifford H Van Meter, MD,

Optimal dose and mode of delivery of Na+/H+ exchange-1 inhibitor are critical for reducing postsurgical ischemia-reperfusion injury Joel S Corvera, MD,

Vascular Endothelial Growth Factor Attenuates Myocardial Ischemia-Reperfusion Injury Zhengyu Luo, Maurizio Diaco, Toyoaki Murohara, Napoleone Ferrara,

Reactive hyperemia during early reperfusion as a determinant of improved functional recovery in ischemic preconditioned rat hearts Annie Rochetaing,

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Heat shock improves recovery and provides protection against global ischemia after hypothermic storage Ashok Gowda, MS, Chunjie Yang, MD, Gregory K Asimakis,

Richard Lee, Takashi Nitta, Ralph A. Schmid, Richard B

Adam E Saltman, MD, PhD, Walter H Dzik, MD, Sidney Levitsky, MD

Minimally invasive direct coronary artery bypass in a cardiac transplant recipient with allograft vasculopathy Ivan Aleksic, MD, PhD, Jarowit A Piotrowski,

James E. Davies, MD, Stanley B. Digerness, PhD, Cheryl R

Ascending versus descending aortic balloon

Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor Yuka Uchiyama,

David J Chambers, PhD, David J Hearse, DSc

Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia Manuel Galiñanes, MD, PhD, Ryszard.

Håvard Nordgaard, MD, Nicola Vitale, MD, PhD, Rune Haaverstad, MD, PhD

Skeletal muscle ventricle aortic counterpulsation: function during chronic heart failure Bhavik G Patel, MD, Sachin H Shah, MD, Lou I Astra, MD, Robert.

Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow Patrick E Parrino, MD, Victor E Laubach, PhD, John R.

Andrew D Cochrane, Shobhna Pathik, Joseph J Smolich, Robert A

Transmural Differences in Myocardial Function and Metabolism During Direct Left Ventricular to Coronary Artery Sourcing Sandra de Zeeuw, PhD, Cornelius.

Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi.

Inhibition of the pacemaker current: a bradycardic therapy for off-pump coronary operations Alain Bel, MD, Louis P Perrault, MD, PhD, Bouchaib Faris,

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

Renato Faro, PhD, Yoshiya Toyoda, MD, James D

Intraoperative assessment of coronary artery bypass graft: transit-time flowmetry versus angiography Hankei Shin, MD, Ryohei Yozu, MD, Atsuhiro Mitsumaru,

Left Ventricular End-Diastolic Pressure Predicts Survival in Coronary Artery Bypass Graft Surgery Patients Jeevan Nagendran, MD, PhD, Colleen M. Norris,

Presentation transcript:

Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn R Gaudette, MSc, Irvin B Krukenkamp, MD The Annals of Thoracic Surgery Volume 68, Issue 3, Pages 844-849 (September 1999) DOI: 10.1016/S0003-4975(99)00809-7

Fig 1 Schematic diagram of experimental protocol. Hearts were subdivided into groups receiving one of the five preconditioning stimuli shown. Control hearts did not receive any stimulus before regional ischemia. (l-NAME = NG-nitro-l-arginine methyl ester; IPC = ischemic preconditioning; LAD = left anterior descending coronary artery.) The Annals of Thoracic Surgery 1999 68, 844-849DOI: (10.1016/S0003-4975(99)00809-7)

Fig 2 Left ventricular end-diastolic pressure. Ischemic preconditioning (IPC) or drug infusion occurred before 0 on the time line. Regional ischemia occurred from 0 to 60 minutes, and reperfusion from 60 to 120 minutes. Data are shown as mean ± SEM. (l-NAME = NG-nitro-l-arginine methyl ester; LARG = l-arginine; ESM = esmolol; NIP = nipradilol.) The Annals of Thoracic Surgery 1999 68, 844-849DOI: (10.1016/S0003-4975(99)00809-7)

Fig 3 Left ventricular peak developed pressure. Peak developed pressure was defined as the difference between end-systolic pressure and end-diastolic pressure. Data are shown as mean ± SEM. ∗ = p < 0.05 versus control. See Figure 2 for abbreviations and events time table. The Annals of Thoracic Surgery 1999 68, 844-849DOI: (10.1016/S0003-4975(99)00809-7)

Fig 4 Action potential duration at 50% repolarization (APD50). Data are shown as mean ± SEM. ∗ = p < 0.05 versus control. See Figure 2 for abbreviations and events time table. The Annals of Thoracic Surgery 1999 68, 844-849DOI: (10.1016/S0003-4975(99)00809-7)

Fig 5 Infarct size for each heart is marked with an X. Bars indicate mean ± SEM for each group of hearts. Infarct sizes are based on the infarcted area as a percentage of the left ventricle at risk. ∗ = p < 0.05 versus control and l-NAME + l-arginine. See Figure 2 for abbreviations. The Annals of Thoracic Surgery 1999 68, 844-849DOI: (10.1016/S0003-4975(99)00809-7)

Fig 6 Coronary flow throughout the experiments. Data are shown as mean ± SEM. ∗ = p < 0.05 versus control and l-arginine. See Figure 2 for events time table. The Annals of Thoracic Surgery 1999 68, 844-849DOI: (10.1016/S0003-4975(99)00809-7)