W. Krajewski, M. Kucharska, B. Pilacik, M. Fobker, J. Stetkiewicz, J

Slides:

Advertisements

Similar presentations

Hematocrit Response and Risk Factors for Significant Hematocrit Elevation with Implantable Testosterone Pellets Russell P. Hayden, Nelson E. Bennett,

Advertisements

Has disability discrimination legislation changed the legal framework for epilepsy in the United Kingdom? Philip Lee Seizure - European Journal of Epilepsy

T. Tedore British Journal of Anaesthesia

The Methylenetetrahydrofolate Reductase 677C→T Polymorphism as a Modulator of a B Vitamin Network with Major Effects on Homocysteine Metabolism Steinar.

Antiemetic and analgesic-sparing effects of diphenhydramine added to morphine intravenous patient-controlled analgesia T.-F. Lin, Y.-C. Yeh, Y.-H. Yen,

Parkinson's disease and anaesthesia

Lidocaine use in ultrasound-guided femoral nerve block: what is the minimum effective anaesthetic concentration (MEAC90)?† A.M. Taha, A.M. Abd-Elmaksoud

A. Sankar, S.R. Johnson, W.S. Beattie, G. Tait, D.N. Wijeysundera

A different use of visual analytic techniques in anaesthetics

Differential effects of halothane and sevoflurane on hypoxia-induced intracellular calcium transients of neonatal rat carotid body type I cells† J.J.

Vitamin A and lung function in CF

Dose adjustment of anaesthetics in the morbidly obese

Long-term functional outcome and performance status after intensive care unit re- admission: a prospective survey N. Conlon, B. O'Brien, G.P. Herbison,

P.W. Buczkowski, F.N. Fombon, E.S. Lin, W.C. Russell, J.P. Thompson

Inflating LMA with normal saline: 14 yr after

Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats A Dahan, A Yassen, H Bijl, R Romberg, E Sarton, L.

L.M. Ferguson, G.B. Drummond British Journal of Anaesthesia

Pain after orthopaedic surgery: differences in patient reported outcomes in the United States vs internationally. An observational study from the PAIN.

Assessing fluid responsiveness during open chest conditions

Intraoperative thoracic epidural anaesthesia attenuates stress-induced immunosuppression in patients undergoing major abdominal surgery† O. Ahlers, I.

Prevalence of anaemia before major joint arthroplasty and the potential impact of preoperative investigation and correction on perioperative blood transfusions

A. A. Klein, T. Collier, J. Yeates, L. F. Miles, S. N. Fletcher, C

Neuromuscular junction in health and disease

Premedication with controlled-release oxycodone does not improve management of postoperative pain after day-case gynaecological laparoscopic surgery

B. Allaouchiche, F. Duflo, J.-P. Tournadre, R. Debon, D. Chassard

Faster wash-out and recovery for desflurane vs sevoflurane in morbidly obese patients when no premedication is used L. La Colla, A. Albertin, G. La Colla,

Nitrous oxide for monitoring fluid absorption in volunteers†

K.J. Chin British Journal of Anaesthesia

Regional cerebral metabolic rate (positron emission tomography) during inhalation of nitrous oxide 50% in humans P. Reinstrup, E. Ryding, T. Ohlsson,

Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous.

Maintenance of stable cuff pressure in the Brandt™ tracheal tube during anaesthesia with nitrous oxide F. Karasawa, T. Okuda, T. Mori, T. Oshima British.

Expertise in practice: an ethnographic study exploring acquisition and use of knowledge in anaesthesia A. Smith, D. Goodwin, M. Mort, C. Pope British.

M.C. Alvarado, K.L. Murphy, M.G. Baxter British Journal of Anaesthesia

Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers G Cammu,

Remifentanil target-controlled infusion vs propofol target-controlled infusion for conscious sedation for awake fibreoptic intubation: a double-blinded.

Assessment of healthcare professionals’ knowledge of managing emergency complications in patients with a tracheostomy† P. Casserly, E. Lang, J.E. Fenton,

H. Beloeil, J.-X. Mazoit, D. Benhamou, J. Duranteau

Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability D.G. Williams, A. Patel, R.F.

The output of two sevoflurane vaporizers in the presence of helium

Table of contents The Journal for Nurse Practitioners

FastrachTM tubes: modifying the design for use with the LMA CTrachTM?

Distraction and interruption in anaesthetic practice

M. Yamakage, N. Hirata, H. Saijo, J-I. Satoh, A. Namiki

Comparison of 1% and 2% lidocaine epidural anaesthesia combined with sevoflurane general anaesthesia utilizing a constant bispectral index A Shono, S.

H.E. Schulenburg, C. Sri-Chandana, G. Lyons, M.O. Columb, H.A. McLure

Effect of epinephrine on epidural, intrathecal, and plasma pharmacokinetics of ropivacaine and bupivacaine in sheep M. Ratajczak-Enselme, J.-P. Estebe,

Do old pharmacokinetic parameter estimates predict new data?

Is age a predictor of mortality in a UK medical high dependency unit?

Direct measurement of nitrous oxide kinetics†

Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthetized dogs: actual versus predicted values Ezzine S. , Varin.

Reviewer Acknowledgment

Effects of ultrasound guidance on the minimum effective anaesthetic volume required to block the femoral nerve A. Casati, M. Baciarello, S. Di Cianni,

O. Tirel, E. Wodey, R. Harris, J.Y. Bansard, C. Ecoffey, L. Senhadji

Table of contents The Journal for Nurse Practitioners

TOF count at corrugator supercilii reflects abdominal muscles relaxation better than at adductor pollicis† K. Kirov, C. Motamed, S.-K. Ndoko, G. Dhonneur

S. Caron, J. Berton, L. Beydon British Journal of Anaesthesia

The effect of ephedrine on intubating conditions and haemodynamics during rapid tracheal intubation using propofol and rocuronium M.D. Gopalakrishna,

H. Schlotterbeck, R. Schaeffer, W. A. Dow, Y. Touret, S. Bailey, P

Teamwork, communication, and anaesthetic assistance in Scotland

Influence of ambient light on cerebral oximeters

G. Lockwood British Journal of Anaesthesia

Diffusion of nitrous oxide into the pleural cavity†

J. Bromilow, T. Corcoran British Journal of Anaesthesia

Rocuronium plasma concentrations during three phases of liver transplantation: relationship with early postoperative graft liver function†‡ L. Gao, I.

Fibrinogen plasma concentration before delivery is not associated with postpartum haemorrhage: a prospective observational study O. Karlsson, A. Jeppsson,

Another case of obstruction to an anaesthetic circuit

D.A. Rowney, R. Fairgrieve, B. Bissonnette

Effect of concentration of local anaesthetic solution on the ED50 of bupivacaine for supraclavicular brachial plexus block† P.K. Gupta, P.M. Hopkins

Plasma lidocaine concentrations following insertion of 2% lidocaine gel into the uterine cavity after uterine balloon thermal ablation G.F. Rousseau,

Narcotrend-assisted propofol/remifentanil anaesthesia vs clinical practice: does it make a difference? I. Rundshagen, T. Hardt, K. Cortina, F. Pragst,

Presentation transcript:

Impaired vitamin B12 metabolic status in healthcare workers occupationally exposed to nitrous oxide W. Krajewski, M. Kucharska, B. Pilacik, M. Fobker, J. Stetkiewicz, J.-R. Nofer, T. Wrońska-Nofer British Journal of Anaesthesia Volume 99, Issue 6, Pages 812-818 (December 2007) DOI: 10.1093/bja/aem280 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 1 Distribution of study subjects with elevated tHcy levels among groups categorized by various plasma vitamin B12 concentrations. The proportion of subjects with tHcy exceeding cut-off value in the subsets of exposed and control groups with low (150–250 pmol litre−1), border low (250–300 pmol litre−1), medium (300–350 pmol litre−1), and high (>350 pmol litre−1) is shown. Plasma tHcy>12.8 µmol litre−1 reflecting 95th percentile in the control group was adopted as a cut-off value discriminating subjects with normal and elevated tHcy levels. Note markedly attenuated relationship between tHcy and vitamin B12 concentration in operating theatre nurses exposed to anaesthetics. British Journal of Anaesthesia 2007 99, 812-818DOI: (10.1093/bja/aem280) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 2 Relationship between vitamin B12 and tHcy levels and the magnitude of N2O exposure. Correlation between plasma vitamin B12 (a) and tHcy (b) levels and N2O concentrations determined in the ambient air in operating theatres. Spearman's rank correlation test: (a) r=−0.22; P=0.038; (b) r=0.53; P<0.001. Distribution of study subjects exposed to N2O between vitamin B12 and tHcy quartiles in control (unexposed) group. The proportion of subjects exposed to low and high N2O concentration in the ambient air in each quartile of vitamin B12 and tHcy calculated for the control group is shown. The proportion of control subjects in each interval is by definition 25%. (c) Distribution between vitamin B12 quartiles. (d) Distribution between tHcy quartiles. Double OEL (2×OEL=360 mg m−3) was adopted to discriminate between ‘low’ and ‘high’ exposure groups. *P<0.01, **P<0.001 high-exposed vs unexposed group (Fisher's exact test). No significant difference was observed between lowexposed and unexposed groups. British Journal of Anaesthesia 2007 99, 812-818DOI: (10.1093/bja/aem280) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions