Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled.

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Presentation transcript:

Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled trial Mark D. Farrar, PhD, Raqib Huq, MB ChB, Sarah Mason, PhD, Anna Nicolaou, PhD, Kayleigh A. Clarke, PhD, Tristan P. Dew, PhD, Gary Williamson, PhD, Rachel E.B. Watson, PhD, Lesley E. Rhodes, MD Journal of the American Academy of Dermatology Volume 78, Issue 2, Pages 414-416 (February 2018) DOI: 10.1016/j.jaad.2017.08.021 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Ultraviolet radiation (UVR)-induced cyclobutane pyrimidine dimers (CPD) in skin from a randomized, controlled study of 12 weeks of supplementation with green tea catechins and vitamin C versus placebo. Representative immunohistochemistry and quantification of CPD in UVR-exposed (3 × minimal erythema dose; MED) and unexposed skin at baseline and postsupplementation. Active n = 20 subjects, placebo n = 24 subjects. Scale bar = 50 μm. Journal of the American Academy of Dermatology 2018 78, 414-416DOI: (10.1016/j.jaad.2017.08.021) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Time course of ultraviolet radiation–induced cyclobutane pyrimidine dimers (CPD) in skin at baseline and after 4 weeks supplementation with green tea catechins and vitamin C. Data are mean + SD number of CPD-positive cells/1000 μm2 epidermis in unexposed skin (0 hours) and at 0.25, 6, and 24 hours after UVR exposure of skin. n = 5 subjects. Journal of the American Academy of Dermatology 2018 78, 414-416DOI: (10.1016/j.jaad.2017.08.021) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions